多西环素对哮喘大鼠血清ige、肺组织磷酸化p38的影响

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1、荚天捅要controlgroup(F=58．737，P<0．01)、(F=89．782，P<0．01)．3．2TheMMP-9levelofratsamonggroupsMMP．9：Thecomparisoninasthmagroup(O．52+0．06)andinterventiongroup(0．394．0．06)wassignificantlyhigherthenthatofcontrolgroup(0．24士0．06)(F=13．45，P

2、ationinasthmagroup(229．444．28．34)wassignificantlyhigherthenthatofinterventiongroup(169．604．57．84)，andthedifferencewasstatisticallysignificant(，尸

3、inexpressionofphosphorylatedp38mitogen—activatedproteinkinaseinlungtissueamonggroups．Theresultsshowthatthedifferenceofphosphorylatedp38／13一actionexpressionlevelsinasthmagroup(O．494．0．01)wassignificantlyhigherthenthatofinterventiongroup(O．314．0．01)，andthedifferencewasstatisticallysig

4、nificant伊

5、fairwaythroughthedecliningofinflammatorycells．Inaddition，thedecreasedexpressionlevelofMMP一9bydoxycyclineresultedinairwayremodelingmitigation．BasedontheinfluenceofserumIgEandtheproteinexpressionofphosphorylatedp38mitogen—activatedproteinkinaseinlungtissue，Doxycyclinecanameliorateairw

6、ayinflammationandairwayremodelingandairwayhyperresponsiVeness，whichmaybethecrucialmechanismfortheasthmatherapy．Inthefuture，DoxycyclinemaybecomeanpromisingcandidateforC1jnicaltreatmentofasthma．6英文摘要_-_————————————————————————————————————————————————————————————一Keywords：asthma；rat；ai

7、rwayinflammation；airwayremodeling；Doxycycline；MMP一9：IgE；Phosphorylatedp38mitogen—activatedproteinkinase————————————————————————————————-————————————————————-—————————_h—————————————__-————————————————●-__———————————————————————_—-——————————————————-—-——————_—一————————一一7研究论文多西环素对哮喘大

8、鼠血清IgE、肺组织磷酸化p38的影响