益气活血中药对脑出血大鼠脑内tsp-1、tsp-2及其受体cd36蛋白表达的影响 (1)

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1、硕士学位论文英文摘要improvingmicrocirculationandhypoxicischemia，protectingbraincells，promotinghematomaabsorbingandbrainedemadisappearingandInhibitinginflammatoryresponse．Accompanyingtheabsorptionofhematomaandedemaandthesubsidenceofinflammatory,Damagedmicrovascularsystemwillreconstructinthefocalzonethrou

2、ghangiogenesisthenthehemoperfusionofinjuredzoneCallberecoveredandthebraintissuecanberepaired．Theangiogenesisisdoublelyregulatedbypromotiveandinhibitivefactors．TSRsequenceofthrombospondins—I(TSP-1)andthrombospondins-2(TSP．2)cancombinewithitsreceptorCD36tocauseendothelialcellapoptosis，andinhibit

3、theangiogenesis．Therefore，wesupposethatthemechanismofYiqiHuoxueChineseHerbsusedinICHmayadjusttheexpressionofTSP一1、TSP一2andtheirreceptorCD36tolessenorpostponeingtheinhibitionofangiogenesisininjuredzone，tochangetheprocessofangiogenesisandtoacceleratetherepairofbraintissue，thenplayaroleof“Removin

4、gStasisandPromotingNew’’．ThisexperimentuseWesternbloRingtoexaminetheexpressionsofTSP-1、TSP一2andtheirreceptorCD36inratbrains．ThroughobservingtheexpressionrulesofTSP．1、TSP_2andCD36ininjuredzoneofICHratbrainandthechangerulesafterinterventionofYiqiHuoxueChineseHerbs，wetrytoinitiallyapproachthemech

5、anismofYiqiHuoxueChineseHerbsonreconstitutionofvesselsystemintheinjuredzoneofratbrainafterICH．V硕士学位论文英文摘要Methods：15SDratswererandomlydividedintosixgroupsincludingnormalcontrolgroup(n=5)，shamcontrolgroup(n=30)，ICHmodelcontrolgroup(n=30)，Yiqitherapygroup(n=30)，HuoXuetherapygroup(n=30)andYiqiHuox

6、uetherapygroup(n=30)．ByinjectingcollagenasetypeVIIstereotaxicallyintorightglobus，ICHmodelwasmade．Yiqi，HuoXueandYiqiHuoxuetherapygroupwererespectivelyadministeredatYiqidecoction，HuoxuedecoctionandSupplementedYangSupplementingFiveReturningDecoction(补阳还五汤)．Atthe1d，4d，7d，14d，21dand28dafteroperatio

7、n，5ratswererandomlychosenfromeachgrouptobesacrificedthroughdecapitatedmethodandbraintissueofhematomazonewerederived．UsingWesternblottingtoexaminetheexpressionsofTSP一1、TSP一2andCD36inratbrains．AlltheExperimentalDatawereanalyzedbyStatistic