kai1与e-cadherin在上皮性卵巢癌中的表达及相关性研究

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1、STUDYOFEXPI之ESSIONANDSIGNIFICANCEOFKAI1ANDE．CADHERININEPITHELIALOVARIANCANCERPostgraduate：Yifang．ZhangTutorProf．：Ouozhi．LinSpecialit)，：ObstetricsandGynecologyAbstractObjective：ToinvestigatetheexpressionofmetastasissuppressorgeneKAIIandtheadhesionmoleculeE-cadherininEOCandtheirrel

2、ationshipwiththeclinicohistologicalfeaturesoftheEOC．ToexplorethepotentialrolesofKAllandE-cadherininthedevelopmentoftheEOC．Methods：ExpressionofKAllandE-cadherinin50casesofEOC，20casesofbenigntumorand15casesofnormalovarytissue．DiagnosedbytheaffiliatedhospitaloftaishanmedicaluniverSi

3、tyandthecentralhospitaloftan’anduringjan2000anddec2007，weredetectedimmunohistochemically．Theaverageageofthe50casesofEOCis53．6．the50casesofEOCincludes30serouscystadenomaofovary，12mucouscystadenomaofovary,8Endometrioidcarcinoma；11stageI，9stageII，20stageIII，10stageIVbyFIGOstaging；8G

4、I，l6G2，26G3bydifferentiation．Statisticalanalysiswasperformed、机tllstatisticalprogramforsocialsciences13．0software，usingnonparametrictestandChi-square；thesurvivalofthesepatientsanalyzedbymultivariateCoxregressionanalysis．Statisticallysignificantlevelwasconsideredas“alphaequalsO．05”

5、．Results：1．ThepositiveratesofKAllin50casesofEOCwere48．0％，in20casesofbenigntumorwere85．0％，in15casesofnormalovarytissueswere100．0％．1rIleexpressionofKAllinEOCandinthebenigntumorsweresignificantdifferences弱wellaSinEOCandinnormalovarytissues(P<0．05,P<0．05)．rnleexpressionofKAnWaSnosign

6、ificantdifferencesinthebenigntumorsandinnormalovarytissues(P>0．05)．田忙expressionofKAUinEOCisrelatedwiththehistologicalgrade，FIGOstaging，lymphnodemetastasisandcancerousascits(P<0．05)．buttheexpressionisnorelated、ⅣitIltheageandhistologictype(P>0．05)．2．ThepositiverateofE-cadherinin50c

7、asesofEOCwere42．0％，in20casesofbenigntBmorwere70．0％，in15casesofnormalovarytissueswerezero．111eexpressionofE·cadherinwassignificantdifferencesbetweenEOCandthebenigntumors(P．<0．05)．The3expressionofKAIIinEOCisrelatedwiththehistologicalgrade，FIGOstaging，lymphnodemetastasisandcancerous

8、ascits(P<0．05)，buttheisnoreliedwiththeag