lef对iga肾病患者尿tgfβ1的相关性研究

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1、大连医科大学硕士学位论文Therelationshipofurinarytransforminggrowthfactor—D1(TGF—p1)onLeflunomideincombinationwithprednisoloneinIgAnephropathyMasterdegreecandidate：ChangjingSupervisor：ProfesserLiushuxinMajor：InternalMedicinAbstractObjective：Toobservetheeffectofleflunomide(LE

2、F)incombinationwithmedium／lowdoseprednisoloneintreatmentofIgAnephropathyanditsinfluenceonthelevelofurinarytransforminggrowthfactor-ill(TGF—p1)．Methods：FromJanuary2009toOctomber2012，60patientswithbiopsyconfirmedIgAnephropathyinasinglecenterinYantai，谢thaLeeSMKgrda

3、dofII～Ⅳ．urinaryprotein1．0-3．Og／24hwereassignedrandomlytotwogroups：LEFgroup(n=30)，prednisolonegroup(n=30)．PatientsofLEFgroupweretreatedLEF(30mg／dfor3daysfollowedby20mg／d)plusprednisolone(0．5mg．kgq．dq,max40mg／d，after4-6weeksoftherapy，thedoseofprednisolonewasreduce

4、d)．Patientsofprednisolone(O．5mg．kg-1．d-Imax40mg／d，after8-12weeksoftherapy，thedoseofprednisolonewasreduced)．Enzymelinkedirnmunosorbentassay(ELISA)wasusedtodetecttheurinaryTGF-plexcretionlevelbeforeand6monthsaftertreatment．Results：Beforetreatmentand6monthsaftertre

5、atment，theurinaryTGF一81andtheproteinuriainLEFgroupdecreasedsignificantly(p

6、eatininelevel(r=0．472，P=0．ooo)．CompleteremissionrateWas46．4％inLEFgroupand16．5％inprednisolonegroup；Totalresponseratewere85．7％and51．9％，respectively．Thedifferencewasstatisticallysignificant(p<0．05)．Theincidenceofsideeffectswere17．8％and11．1％．Thedifferencewasnotstati

7、sticallysignificant(p>O．05)．Conclusions：OurfindingsmaysuggegthatLEFplusmediumorlowdoseprednisoloehasabeRereffectthanthatofthesamedoseofhormone；oneofthemechanismmightbetheinhibitionofTGF-91．Keywords：IgAnephropathyurinaryTGF-81LEFglucocorticoid2大连医科大学硕士学位论文LEF对IgA

8、肾病患者尿TGF一131的相关性研究硕士生姓名：指导教师：专业名称：常靖刘书馨教授内科学日

9、J吾IgA(immunoglobulinA)肾病是指以IgA或以IgA为主的免疫球蛋白沉积在肾小球系膜区并产生一系列临床及病理变化的一种原发性肾小球疾病，系膜增殖是其病理组织学特征，常伴有不同程度的肾小球损伤和肾功能障碍，是终末期肾功能衰竭