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ID:32329617
大小:2.73 MB
页数:37页
时间:2019-02-03
《dna修复基因遗传多态性与上皮性卵巢癌患者铂类化疗临床预后关系的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、英文摘要treatedbyplatinum-basedchemotherapy.4Themedianoverallsurvival(0S)ofpatientscarryingLys/LysandLys/Gln+Gln/GlngenotypeofXPCLys939Glnpolymorphismwere31.1and27.8,respectively.Kaplan-Meierestimatesdemonstratedthatstatisticalsignificantdifferencewasfoundbetweenthegenotypes
2、andPFSofEOCcases(P=0.048).Cox’Smultivariateanalysissuggestedthatthepatientsofepithelialovariancancerwi也theGinallelehadanincreasedriskofdeath(mbl.75;95%CI=1.06·2.91)comparedwiththosewiththeLys/Lysgenotype.5TherearenoassociationsbetweentheXPC(Ala499Val,PAT十/-),ⅫD(Asp312Asn
3、,Lys751Gln),XRCCl(Ar9194Trp,Ar9280HisandAr9399Gln)polymorphismsandpatientssurvival、析thepithelialovariancancerwhentreatedbyplatinum-basedchemotherapy.Conclusion:1NosignificantdifferencesingenotypeandallelotypedistributionsofeightSNPs(XRCC1Ar9194Trp,Ar9280His,Ar9399Gln;XPD
4、Asp312Asn,Lys751GlnandXRCC1Ar9194Trp,Ar9280His,Ar9399Gln)werefoundbetweenrespondersandnotrespondersofallpatients.2TherealenoassociationsbetweentheXPCAla499Val,Lys939Gln,PA飞+hXPDAsp312Asn,Lys751GinandXRCClAr9194Trp,Ar9280His,Ar9399Glnpolymorphismsandpatientsrecurrencewith
5、epithelialovariancancerwhentreatedbyplatinum-basedchemotherapy.3111eresultsindicatedthattheXPCLys939Glnpolymorphismmaycorrelatewithclinicaloutcomeofpatientswithepithelialovariancancerwhentreatedbyplatinum-basedchemotherapyinNorthernChina.4Therearenoassociationsbetweenthe
6、XPC触a499Val,PAT+/一;XPDAsp312Asn,Lys751GlnandXRCClAr9194Trp,Ar9280His,Ar9399GlnpolymorphismsandOSofepithelialovariancancerpatientswhentreatedbyplatinum.basedchemotherapy.Keywords:XPC,XPD,XRCCl,epithelialovariancancer,platinum一5英文摘要basedchemotherapy,clinicaloutcome6研究论文DNA
7、修复基因遗传多态性与接受铂类化疗的上皮性卵巢癌患者临床预后关系的研究前言在卵巢原发性恶性肿瘤中,起源于表层上皮组织的上皮性卵巢癌(EOC)约占90%。目前,以铂类为基础的联合化疗为EOC患者术后的一线化疗方案,约70%的病人可以达到临床完全缓解【l】。尽管患者铂类化疗的初始应答率较高,但多数病人在术后3年内出现肿瘤复发,导致患者的5年生存率仅为20%.、一40%12]。肿瘤细胞对化疗药物,尤其是铂类化合物的耐药被认为是患者预后不良的主要原因。因此,如果能够找到铂类抵抗的分子标记物,用来靶向逆转铂类耐药以改善患者预后,将会是卵巢癌治疗中的
8、重大突破。铂类药物如顺铂、卡铂、草酸铂等的作用机理是通过进入肿瘤细胞与DNA结合,形成Pt-DNA加合物,导致DNA链内或链间交联,引起DNA复制障碍,从而抑制肿瘤细胞分裂,导致肿瘤细胞凋亡。DNA损伤修复
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