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ID:32283029
大小:1.42 MB
页数:52页
时间:2019-02-02
《角膜缘上皮移植治疗眼表疾病的临床的研究 (1)》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中文摘要皮移植联合术中、术后应用丝裂霉素C(c组),术后随访6—18个月。平均12个月。二、选择12例(12眼)急性眼化学烧伤患者,于伤后3—6d行自体角膜缘上皮移植联合新鲜人羊膜移植重建眼表,随访观察羊膜植片情况、角膜透明性和视力恢复情况。结果:一、角膜缘上皮移植联合丝裂霉素C防止翼状胬肉术后复发的疗效:A组16例复发,复发率20.O%;B组6例复发,复发率8.6%;C组2例复发,复发率2.9%。A组分别与B组、C组相比差异均有统计学意义:A组与B组相比()(2=3.896,P<0.05),A组与C组NtP,(X2=10.390,P2、组相比(x21.193,P>O.05),差异无显著性。A组角膜上皮愈合天数为5.28士O.67天,B组为5.73士0.70天,C组为4.57士0.60天。C组愈合时间显著快于A、B组(F--54.469,P<0.01)。二、自体角膜缘上皮移植与新鲜羊膜对急性眼化学烧伤的修复作用:随访6—12个月,12例12眼眼表面重建成功。未见新鲜羊膜植片急性排斥反应及感染发生;角膜上皮愈合,无新生血管、假性胬肉及角膜上皮缺损。7眼角膜透明,3眼角膜云翳,1眼角膜斑翳,1眼角膜白斑。视力均不同程度的提高,ll眼脱盲。结论:一、自体角膜缘上皮移植联合丝裂霉素C可有效防止翼状3、胬肉术后复发,角膜上皮愈合时间短,可达到重建正常眼表、加快创面修复、减少术后并发症及复发率等目的,是治疗翼状胬肉一种较理想的手术方式。二、新鲜人羊膜移植联合自体角膜缘上皮移植是修复急性眼化学烧伤的一种有效方法。关键词:翼状胬肉角膜缘结膜羊膜移植丝裂霉素C化学烧伤Ⅱ塑主堂竺丝塞ClinicalstudyoflimbalepithelialautograftfortreatmentofocularsurfacediseasesName:GongYu—BoSupervisor:LuXiao—HeBackground:1、PterygiumisacoF/inlon4、kindofocularsurfacediseases,theprimarytreatmentofpterygiumisperformedbysurgery,buttherecurrencerateafterexcisionofpterygiaishigh.Therearealotofdifficultiesin廿_eatingpterygiumandpreventingtherecurrenceofpterygium.Withthefoundationanddevelopmentoflimbalstemcell。limbalepithelialautog5、rafthasprovidedanewviewfortreatingocularsurfacediseases.InanefforttodetermineawaytOreducetherecurrenceofpterygium,throughcomparingtheefficacyandsafetyofdifferentsurgicalmethodsafterexcisionofpterygiurn,judgingtheefficiencyofHmbalepithelialautograftcombinedwithmitomycinC(MMC)tointr6、aoperativeandpostoperativepatientsforinhibittingthepterygiumrecurrenceafteroperation,wecanreachabettertherapeuticalprojectfortreatingpmrygium.2、Chemicalbarnscallinducecomplicatedpatholo#calandphysiologicalreactionsandcauseseveredamagetotheeye,notonlyofitssurface,butalsoofitsdeepsl7、a'uctores.Therefore。itisimportantforUStotakeeffectiveandurgentmeasurestoprotecteyeandsavevisionfunctions.【jmbalepitheliaprovidestemcell,whichcallrestorecornealtransparencyandreconslructionocularsurface.Amnioticmembrane(AM)hasbeenfoundtoexertitseffectsbyactingasasubstratefortheABST8、RACTgrowthofocularsurfaceepitheli
2、组相比(x21.193,P>O.05),差异无显著性。A组角膜上皮愈合天数为5.28士O.67天,B组为5.73士0.70天,C组为4.57士0.60天。C组愈合时间显著快于A、B组(F--54.469,P<0.01)。二、自体角膜缘上皮移植与新鲜羊膜对急性眼化学烧伤的修复作用:随访6—12个月,12例12眼眼表面重建成功。未见新鲜羊膜植片急性排斥反应及感染发生;角膜上皮愈合,无新生血管、假性胬肉及角膜上皮缺损。7眼角膜透明,3眼角膜云翳,1眼角膜斑翳,1眼角膜白斑。视力均不同程度的提高,ll眼脱盲。结论:一、自体角膜缘上皮移植联合丝裂霉素C可有效防止翼状
3、胬肉术后复发,角膜上皮愈合时间短,可达到重建正常眼表、加快创面修复、减少术后并发症及复发率等目的,是治疗翼状胬肉一种较理想的手术方式。二、新鲜人羊膜移植联合自体角膜缘上皮移植是修复急性眼化学烧伤的一种有效方法。关键词:翼状胬肉角膜缘结膜羊膜移植丝裂霉素C化学烧伤Ⅱ塑主堂竺丝塞ClinicalstudyoflimbalepithelialautograftfortreatmentofocularsurfacediseasesName:GongYu—BoSupervisor:LuXiao—HeBackground:1、PterygiumisacoF/inlon
4、kindofocularsurfacediseases,theprimarytreatmentofpterygiumisperformedbysurgery,buttherecurrencerateafterexcisionofpterygiaishigh.Therearealotofdifficultiesin廿_eatingpterygiumandpreventingtherecurrenceofpterygium.Withthefoundationanddevelopmentoflimbalstemcell。limbalepithelialautog
5、rafthasprovidedanewviewfortreatingocularsurfacediseases.InanefforttodetermineawaytOreducetherecurrenceofpterygium,throughcomparingtheefficacyandsafetyofdifferentsurgicalmethodsafterexcisionofpterygiurn,judgingtheefficiencyofHmbalepithelialautograftcombinedwithmitomycinC(MMC)tointr
6、aoperativeandpostoperativepatientsforinhibittingthepterygiumrecurrenceafteroperation,wecanreachabettertherapeuticalprojectfortreatingpmrygium.2、Chemicalbarnscallinducecomplicatedpatholo#calandphysiologicalreactionsandcauseseveredamagetotheeye,notonlyofitssurface,butalsoofitsdeepsl
7、a'uctores.Therefore。itisimportantforUStotakeeffectiveandurgentmeasurestoprotecteyeandsavevisionfunctions.【jmbalepitheliaprovidestemcell,whichcallrestorecornealtransparencyandreconslructionocularsurface.Amnioticmembrane(AM)hasbeenfoundtoexertitseffectsbyactingasasubstratefortheABST
8、RACTgrowthofocularsurfaceepitheli
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