国内关于vegf在结直肠癌中表达meta的分析

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1、目录主要缩略词···················································1中文摘要···················································2英文摘要···················································3引言····················································5正文····················································71资料与方法·

2、················································71.1文献资料来源·············································71.1.1检索策略················································71.1.2纳入标准················································71.1.3剔除标准················································71.2统计学处理··

3、·············································72结果······················································72.1文献基本情况··········································72.2文献的一致性检验及发表偏倚·························82.3Meta分析结果·········································83讨论··································

4、···············114存在的问题和展望······································15结论··················································16参考文献··················································17综述··················································22致谢··················································29攻读学位

5、期间发表的学术论文目录·······················30作者声明··················································31个人简历··················································321主要缩略词英文缩写英文全称中文全称VEGFvascularendothelialgrowthfactor血管内皮生长因子ORoddsratio比值比95%CI95%confidenceinterval95%可信区间CRCColorectalCancer结直肠癌CSchi-squ

6、ared卡方检验dfdegreeoffreedom自由度2Iinhomogeneity-squared异质性的平方值1中文摘要目的：探讨血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)在结直肠癌中的表达及意义。方法：检索中国学术期刊全文数据库、维普及万方数据库，收集1989～2011年4月国内公开发表论文，且为VEGF在结直肠癌中表达及意义的独立病例研究，并对文献进行异质性检验，以病例组及对照组比值比（OR值）为效应指标，然后应用Meta分析软件stata11.0对各研究原始数据进行统计处理，计算合并OR值及95%CI,同时给

7、出Meta分析森林图和漏斗图。结果：最终进入系统评价的文献共有26篇病例研究，其中结直肠癌患者1647例，对照组870例，Meta分析结果合并OR为0.175，95%CI为[0.132，0.232]，VEGF表达与结直肠癌浸润深度（P=0.008）、淋巴结转移（P=0.00）、TNM分期（P=0.03）、Duke分期（P=0.00）、3年生存率（P=0.00）及5年生存率（P=0.02）之间存在明显相关，而与结直肠癌肿瘤大小（P=0.53）、年龄（P=0.96）及性别（P=0.43）无明显关联。结论：对目前相关研究结果的Meta分析显示，