盐酸氨溴索渗透泵控释制剂的研制

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1、●’。·‘、It,，‘‘!二L．．■．．一tk目录中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯4研究论文盐酸氨溴索渗透泵控释制剂的研制弓I言”一”“一””一””一””一一“一””一············”·····一”·······““····9第一部分盐酸氨溴索双层渗透泵片的制备前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯···⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯···100日¨看”一”“一””一””一””一””一””一”“一””一”“““”一””一“l材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1l结果···⋯······⋯···⋯····

2、··⋯············⋯···⋯·····················20附图···⋯···⋯⋯···⋯···⋯⋯···⋯···⋯⋯⋯⋯⋯⋯⋯······⋯···25附表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯39讨{仑“一”“一·一““··““·”一”“一······················一“·“····””·46d、结···········⋯·⋯······⋯⋯⋯····!⋯⋯····························48参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯48第二部分盐酸氨溴索渗透泵胶囊的制备前言“一”“一”⋯”一””一”⋯”

3、．．．．”一”⋯”．．““一”⋯”一“⋯．．·5一O刖吾“一”“一””一””一”“”””““”一””””“一””一””一“”一”材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯51结果⋯⋯··一··⋯···⋯······⋯··一········⋯·········”一·········”“·54附图···⋯···⋯⋯⋯⋯⋯⋯⋯···⋯⋯⋯⋯⋯⋯⋯⋯⋯·⋯··⋯···57附表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．．⋯66讨论············································⋯⋯⋯·-···············”69小结··········

4、···⋯⋯···································“·············69参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯70第三部分盐酸氨溴索渗透泵制剂的质量评价’前言···⋯⋯⋯⋯⋯⋯⋯⋯⋯···⋯⋯⋯⋯⋯⋯⋯⋯⋯···⋯⋯···7l刚舌”一””一”“一”“一””一”“一⋯一“一””⋯一”一一””一””一”’7l材料与方法⋯⋯⋯⋯⋯⋯：⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯··71结果···⋯···⋯⋯·········⋯⋯⋯·⋯⋯··⋯··⋯⋯⋯················75附图⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯77附表⋯⋯⋯⋯⋯⋯⋯

5、⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯··，⋯⋯85讨论··⋯⋯·····················⋯··············⋯⋯⋯····⋯⋯⋯⋯·87小结···············⋯⋯⋯··⋯⋯···-⋯-·····⋯···⋯···”一·····⋯···87参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯88第四部分盐酸氨溴索渗透泵制剂Beagle犬体内药动学研究前言“一””“”．．一””一”⋯“一“⋯⋯⋯⋯⋯”一””一“⋯”一””·8—9一月U吾“一””“”“一””一”⋯“一“⋯“一“””“”“””一““一””一”材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯89结果··

6、····⋯·····················⋯····⋯·····⋯···⋯············“····93附图···⋯·⋯⋯···························································96附表···“一“”一“··一···”·””··········⋯“一“·””一““．．““．．一···100讨{念“一””一”一⋯一””一””·······⋯“一”··一··””””一““一”···105以、结”一””一”一一”一一””一””一””⋯⋯⋯一””一””一””一”一·106参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯

7、⋯107结论”一””一”一一””一”．．一“····“”一””一⋯一“一””一””一””·108综述难溶性药物双层渗透泵片的研究进展⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯109致谓

8、-···········································⋯·························1l6个人简历⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯117中文摘要盐酸氨溴索渗透泵控释制剂的研制摘要