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1、缓控释材料在药物制剂中的研究进展摘要随着人们生活水平的不断改善，各类慢性疾病的发病率也逐渐上升，人们对于治疗这类疾病药物的制剂要求也逐步提高，而作为药物辅料的缓控释材料则从某种程度上决定了药物制剂的质量。因此药用缓控释材料的开发和应用成为了改善药物疗效的重中之重。目前应用最多的缓控释材料是高分子材料。本文通过查阅国内与国外相关的文献，阐述了缓控释材料的分类及在医药中的应用，主要介绍了高分子材料在缓释药物制剂中的应用，探讨了高分子载体材料对药物缓释性能的影响及其研究意义与未来发展方向；缓释技术是药物制剂发展
2、的动力，本文简明介绍其发展与应用；最后缓控释制剂的分类：口服、注射、植入、透皮、固体分散体等，通过探讨缓控释制剂的优点，研究了典型缓控释药物在肿瘤、呼吸系统、心血管、糖尿病等疾病的临床应用。随着科技的发展，高分子材料在药物制剂中的应用将更加成熟，进而促进了缓控释制剂向着用药量低且高效安全方向发展，满足缓控释制剂在临床应用中的需求。关键词高分子材料；缓释技术；缓/控释制剂；临床应用III-Researchprogressofslowcontrolledreleasematerialinpharmaceuti
3、calpreparationsAbstractWiththecontinuousimprovementofpeople'slivingstandard,theincidenceofvariouschronicdiseasesisgraduallyincreased,drugsforthetreatmentofthesediseasespreparationforPeople’srequirementsaregraduallyimproved,Whiletheslowcontrolledreleasemat
4、erialsasdrugexcipientsdeterminesthequalityofpharmaceuticalpreparationstosomeextent.Thereforethedevelopmentofpharmaceuticalslowcontrolledreleasematerialsandapplicationhasbecomeatopprioritytoimprovedrugefficacy.Highpolymermaterialismostwidelyappliedslowcont
5、rolledreleasematerialatpresent.ThroughSearchingthedomesticandforeignrelatedliteratures,thispaperexpoundstheclassificationofslowcontrolledreleasematerialsandapplicationsinmedicine,Thispaperdescribesthepolymermaterialintheapplicationofsustained-releasepharm
6、aceuticalformulations,explorestheinfluenceofthepolymercarriermaterialforpropertiesofdrugdeliveryanditssignificanceandfuturedirection;Slowcontrolledreleasetechnologyisthedrivingforceforthedevelopmentofthepharmaceuticalpreparations,thisarticleoffersaconcise
7、introductiontoitsdevelopmentandapplication;Finallydiscussestheclassificationofsustained-releasepreparations:Oral,injective,Implantable,transdermal,soliddispersionandothercontrolledreleaseformulations.Byexploringtheadvantagesofcontrolledreleaseformulations
8、,Studiesclinicalapplicationsofthetypicalslow-releasedrugsincancer,respiratory,cardiovascular,diabetesandotherdiseases.III-Withthedevelopmentoftechnology,theapplicationsofthepolymersinpharmaceuticalformulationswillbe
