丹皮酚干预兔实验性动脉粥样硬化的实验研究

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1、ExPerimentalStudiesonInterventionalEffectofPaeonolonAtheYOsclerotieRabbitsSPeciality:ThebasieresearehonTCMtheoryAuthor:LiuJinTutor:ZhengGuan自uanAbstractObjective:ToexPloretheinierventionaleffeetofPaeonolonexPerimenialatherosclerotierabbitsanditsPossiblemeehanism.Methods:Thirty一sixhealthyNewZeala

2、ndrabbitsweredividedrandomlyiniosixgrouPs:normalgrouP，modelgrouP，medieinegrouP1treatedwithAsPirinof3Omg/kg/d，medieinegrouP11treated诚thPaeonolof37.smg/k留d(lowdosegrouP)，medieinegrouP111treatedwithPaeonolof75mg/kg/d(lniddledosegrouP)，medieinegrouPIVtreatedwithPaeonolof150mg/kg/d(highdosegrouP).All

3、thegrouPswerefedwithhighliPiddietand19fatemulsionoflml/1009fortwelveweeks，butnormalgrouPwasfedwithstandarddiet.Theserumlevelsoftotaleholesterol(TC)，triglyceride(TG)weremeasuredbeforereProducedhighfatdietrabbitsmodelandafterhavereProdueedhighfatdietrabbitsmodelfor4weeks.ThemedicinegrouPswereadmin

4、isteredwithPaeonolorasPirin，andthenormalgrouPandmodelgrouPwereadministeredwithnormalsaline.AllgrouPsadministeredorallywiththesamevolumefor8weeks.Theserurnlevelsoftotaleholesterol(TC)，triglyeeride(TG)，lowdensityliPoProtein(LDL)，highdensityliPoProtein(HDL)wereanalyzedafter8weeks，andthePlasmalevels

5、ofsICAM一l、sVCAM一l、IL一6、VEGFweredetected，andtheserumlevelsofsuPeroxidedismutase(SOD)，malonaldehyd(MDA)weremeasured.AndthePathologiealandmorphologieehangesofaortawereobserved.Results:PaeonolnotoulyeanobViouslylowtheseru们nlevelofTC、TG、LDL一C、MDAandenhaneetheserunnlevelofSOD，butalsoeaninhibittheexPre

6、ssionofsICAM一l、sVCAM一l、IL一6、VEGFofPlasmaandeanProteetthemorphologiealstruetureofaorta.Conclusion:PaeonoleanPreventtheProgressionofatheroselerosis.ThemeehanismsmayeoncemedwithPaeonol’regulatingliPidmetabolismdisouler，redueingthereleaseofeytokines，inhibitingliPidPeroxidationandProteetingvaseularen

7、dotheliumandctc·KeywordsPaeonol:atheroselerosis:bloodliPid;Cytokines:liPidPeroxidation备目录一一︸一匀勺实验研究........................................................................……，..........................................……31实验材料