健脾补肾、泻浊祛瘀法治疗慢性肾功能衰竭的研究

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1、Studyontreatingchronicrenalfailureusingmethodsofinvigoratingspleenandkidney，purgingturbidandremovingbloodstasisSpecialty：ThestudyofKidneyDiseases.InternalMedicineofTCMAuthor：LiMinTutor：ProfessorGuoZhaoanAbstractObjective：Toobservetheclinicaleffectoftreatingchronicrenalfailureusingthemeth

2、odsofinvigoratingspleenandkidney，purgingturbidanditsprotectiveeffectonrenalfunctionandstructureofratswithrenalinterstitialfibrosiscausedbyunilateralureteralobstruction.Todiscussitsmechanismoffunction.Methods：1.120patientswithCRFweredividedrandomlyintotwogroupswiththeratioof1：1，theexperim

3、entalgroupandthecontrolgroup.Patientsintheexperimentalgroup(30cases)wereadministeredwithQudugranules(dispeltoxic)(5gpertime，threetimesaday)，whilethoseinthecontrolgroup(60cases)treatedwithNiaoDuqinggranules(5gpertime，threetimesaday).Thechangesofhemoglobin，urinaryproteinper24hrs，hemoglobin

4、，renalfunction，parathyroidhormone(PTH)，N-actely-β-D-glucosaminidase(NAG)，endothelin(ET)，changesofscoresofsymptomsofsyndromesofdeficiencyofspleenandkidney，turbidandbloodstasiswereobservedintwogroups.Thedifferencesbetweentwogroupswerecompared.2.90maleWistarratsweredividedrandomlyintofivegr

5、oups：theshamoperationgroup，themodelgroup，highdosageQudugranulesgroup(highdosagegroup)，thelow-dosageQudugranulesgroup(lowdosagegroup)andNiaoDuqinggroup(controlgroup).18ratswereineachgroup.Excepttheratsintheshamoperationgroup，theleftureteralsofratswereligatedineachgroup.Medicinewasgiventoe

6、achgroupaccordingtothedesignedconcentrationanddosagefromthedaybeforetheligation.Theratswerekilledonthethird，seventhandfourtheenthdayinbatches.NAGenzymeintheurine，renalfunctionandpathologicalchangesofthekidneywereobserved.Results：1.Aftertwomonthstreatment，thecreatinine，ureanitrogenanduric

7、acidofthepatientswereimproved，NAGenzymeintheurine，endothelinand24hoursurinaryproteinwerelower，hemoglobinwassignificantlyhigher，PTHandscoresofsymptomsdecreaseobviouslyintheexperimentalgroup.2.QudugranulescouldsignificantlyreduceurinaryNAGenzyme，improvethecreatinine，ureanit