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ID:32227975
大小:1.25 MB
页数:24页
时间:2019-02-01
《动态观察结核性脑膜炎脑脊液ifnγ、ada的变化与临床意义》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、·中文论著摘要·动态观察结核性脑膜炎脑脊液IFN-ff、ADA的变化及临床意义目的分析联合检测结核性脑膜炎患者脑脊液中Y干扰素(IFN吖)水平及腺苷脱氨酶(ADA)对结核性脑膜炎的早期诊断价值,以及动态观察脑脊液中IFN吖水平及ADA的水平在结核性脑膜炎病程中的变化及临床意义。方法对结核性脑膜炎患者和血行播散型肺结核患者出现头痛症状而脑脊液正常的患者分别于入院1"-'2d内行腰椎穿刺术,采集新鲜CSF标本8m1,采用ELISA法检测脑脊液中IFN-y含量和酶标法检测脑脊液中ADA,对确诊结核性脑膜炎患者给予标化抗结核治疗方案,分别测定其抗结核治疗后第2周、4周、12周脑脊液中IFNIY水平
2、及ADA的变化。结果研究组中患者脑脊液的IFN吖水平及ADA较对照组明显增高,P值均0.05,脑脊液中IFN.丫水平P<0.05,蛋白的测定结果比较,P>0.05;12周与4周时IFN-y的测定结果比较,P<0.001,蛋白和ADA的测定结果比较,P<0.05。结论联合检测脑脊液qbIFN吖及ADA水平可提高结核性脑膜炎的早期诊断率,且在经过抗结核治疗后,随着病情的好转,其脑脊液蛋白下
3、降过程中脑脊液qbIFN—Y水平及ADA也同时下降,说明在结核性脑膜炎患者脑脊液qbIFN吖水平及ADA可提示病情好转。关键词IFN吖;ADA;结核性脑膜炎;脑脊液;·英文论著摘要·TheChangesandClinicalSignificanceofIFN—y、ADAintheCerebrospinalFluidofTuberculousMeningitisPatientsbydynamicObservationobjectiveToanalysethevalueofearlydianosisandtheclinicalsignificanceinthetuberculousmening
4、itiscoursewithchangesofthelevelsofinterferon·7(IFN-,l,)andtheactivitiesofadenosinedeaminase(ADA)incerebrospinalfluid(CSF)ofthetuberculousmeningitispatientsbycombineddetection.MethodsWecollecttheCSFofthetuberculousmeningitispatientsandthehematogenousdisseminatedpulmonarytuberculosispatientswitllhec
5、atebylumbarpuncture,thenusetheELASAandenzymelabelingmethodtodetectthelevelsofIFN—YandtheactivitiesofADA.Wegivethestandardizedantituberculosistreatmentregimenstothetuberculousmeningitispatientsandthendeterminethe,:bangesofthelevelsofIFN吖andtheactivitiesofADAofCSFatthe2加、4thand12mweek.ResultThelevel
6、sofIFN-丫andtheactivitiesofADAofCSFinresearchgroup(324+85.7,12.97+0.89)sifnificantlyincreasethanthecontrolgroup(45.87+16.8,2.78士0.65),P<0.01.InthedynamicobservationofantituberculosistreatmentregimensthelevelsofIFN-7andtheactivitiesofADAoftuberculousmeningitispatients3(217.85士20.56,8.60士0.72)atthe2叫
7、weekobviouslydecreasethantheinpatienttime(324+85.7,12.97+0.89),P<0.001;andtheproteinsofCSFat廿1e2删week(1.53+0.30)alsodecreasethaninpatienttime(2.43士0.41),P
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