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ID:32214560
大小:2.38 MB
页数:23页
时间:2019-02-01
《血管内皮生长因子、还氧化酶-2在膀胱移行细胞癌中的表达与意义》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、ThepositivestainingofVEGFismainlylocatedincytoplasmIminoritylo—catednucleusmembrance.COX.2proteinwasundetectableinnornlalbladdertissue.Inbladdertransitionalcellcarcinoma,thepositiverateofVEGFwas82%(32/50).Therewassignificantdifferences(P(0.05)whenbladderearci—no
2、magroupcomparedwithnormalgroup.InthegradeI。Ⅱ,III,thepositiveratesofVEGFwere50%(7/14),58%(14,/24),91。7%(11/12)respectively,Therewereriosignificantdifferences{P>0+05)whentheexpressionofVEGFwascomparedwithgradeIandgradeⅡ.ThereweresignificantdifferencesfP<0.05)betwe
3、engradeIandgradeⅢ,and,alsosignificantdifferences(P<0.05)betweengradeIIandgradeHI.Inthetumorstage,theexpressionwashiger(P(0.05)ininvasiontumor(T2~T4)thaninsuperficialtumor(T。~T,).Of50casesbladdercarcinoma。24casewerepositiveexpressionofbothCOX-2aridVEGF,while12cas
4、eswerenegativeexpressionofbothCOX-2andVEGF.TherewasclosecorrelationbetweenCOX一2andVEGFexpression(P<0.051.ConclusionexpressionofCOX-2increasesinhigh—gradebladdertransitionalcellcarcinoma,theover—expressionofCOX一2iscorrelatewiththestageofinvasivetumor.Itprovidesre
5、ferencingindexforresearchofnotonly.theearlyphaseofcarcinogenesisbutalsothedevelopmentandinvasionofbladdercarcinoma.expressionofVEGFincreasesinhigh—gradeandhigh—stagebladdertransitionalcellcarcinoma,theover—expressionofVEGFiscorrelatewiththestageofinvasivetumor.I
6、tprovidestheoreticalfoundationforVEGFmayhavere—lationshipwiththecarcinogenesis,developmentandinvasionofbladdercareino-maexpressionofCOX-2isrelatedtotheexpressionofVEGF.Itisindica—tedthatthereisacertainregulationbetweenCOX.2andVEGF.Theycontributetotheangiogenesis
7、andmetastasisofbladdercarcinomaincoordination.COX-2andVEGFarecorrelatedwiththedevelopmentandmetastasisof·6·bladdercarcinomaincoordination.ItissuggestedthatthepositiveexpressionofCOX-2andVEGFmightbethereferencingindexoftheangiogenesisandmetas。tasisofcarcinoma.Iti
8、sshownthatCOX-2andVEGFmayprovidetheo—reticalfoundationforselectiveCOX-2inhibitoractingasnewehemopreventivestrategyandantiangiogenictherapyforcarcinomainthefuture.Keyw
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