替米沙坦对高血压合并糖尿病患者ir和abi影响的临床分析

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1、HOMA-IR---FPG(mmol／L)*FINS(mIU／L)／22．5。：bloodlipid；innerdiameterofhumeralarteryandflowmediateddiastolicfunction(FMD)；ankleindex(ABI)；andcomparedifferenceintwogroups．5．Statisticalanalysis：Computationdatawassummarizedwithmean+standarddeviation，countingdatawithz2test，alldataWasa

2、nalyzedwithsoftwarepackageofSPSS12．0，P<0．05Wasofstatisticalsignificance．ResultsAftertreatment，bloodpressuredecreasinginexperimentalgroupismoreobvious，SBPdecreasedto148．7+8．8mmHgfroml58．7+8．1mmHg，SBPdecreasedt0150．3-4-7．1mmHgfroml55．4+8．4mmHgincontrolgroup(P<0．05)：Inexperiment

3、algroup，FPGdecreasedto5．9+0．6mmol／Lfrom7．1+0．9mmol／L，PPGdecreasedto9．1+0．7mmol／Lfroml0．24-1．7mmol／L，FTNSdecreasedto14．04-1．6p．IU／Lfroml5．54-1．99lU／L(P<0．05)，PTNSdecreasedto9．14-0．79IU／LLfroml2．24-1．71xlU／L(P<0．05)，ABIgroupincreasedto1．06+0．06fromO．954-0．04(P<0．05)．DiseussionR

4、ecentyearssomescholarsputforwardtheeffectonIRofhepertentionisoneofimportantindexeswhichcanappraiseantihypertensivedrug．Intreatmentofhepertentionweshouldn’tsettlefordecreasingbloodpresuretotheperfectlevelorreducingthesideeffectsofdrug，butthinkmuchadequatelyofinfluenceontheleve

5、lofinsulinandIR，andchooseantihypertensivedrugrationally．StudyshadprovedthereisrelevancybetweenIR、PPARl,andhypertension．AtpresenttheexactmechanismofdecreasingbloodpressurebyPPARYactivation．PartlyduetotheimproveofIR，onthesidemaybethedirecteffectofPPARytobloodvessel．8PPAR7isthei

6、mportantfactorofadjustingATlRexpression，anditshighexpressionCanrestrainbloodincreasing．Afteractiveted，PPAR7Canrestraintheexpressionof1eptinwhichincreasebloodvessel．Inthisstudytelmisartanshowedexactfunctionofdecreasingbloodpressure，furthermorecomparewithamlodipineitcallcontrol

7、bloodpressurebetter，whichmayberelatetoitsdoublemechanismofdecreasingbloodpressure．TelmisartanispartialactivatorofPPAR7．ThePPARyisahndofnuclearhormonereceptor，SOCanimproveRI。SomestudyspromptedthatforpatientswithhypertentionandDM，aftertreatmentbytelmisartanfor12weeks，thelevelof

8、bloodsugarandinsulindecreaseboth．Inthisstudywecandrawthesameconclusi