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ID:32187820
大小:2.50 MB
页数:73页
时间:2019-02-01
《麻芩急支膏贴与原黑膏药咳喘膏的质量分析与比较分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、的薄层鉴别、有效成分的含量测定及离体小鼠透皮率、释放度的比较研究,论证了麻芩急支膏贴新剂型优于传统的黑膏药剂型,证实了黑膏药咳喘膏剂型改革的合理性和可行性。关键词麻芩急支膏贴;咳喘膏;薄层鉴别;含量测定;离体透皮率;释放度ⅥIStudyonQualityAnalysisandComparisonofMaqinJizhiPatchwithKechuanPlasterSpeciality:TheChineseMateriaMedicaAuthor:FangYouniTutor:HanJianweiObj
2、ective:Abstract’-^Throughtheanalyticalmethodsincludingthinlayerchromatography,contentdeterminationontheeffectiveingredientsinMaqinjizhiPatchandcomparedwiththeOriginalBlackPlasterfromthinlayerchromatography,contentdetermination,releaserate,vitropercutan
3、eousrate,whichhasconfirmedthereasonoftheclinicalcurativeeffectofMaqiniizhiPatchisbetterthanthatofOriginalBlackPlasterformthematerialbaseofdrug,releasespeedofdrugingredientsandthevitropercutaneousrate.IthasconfirmedtheformulationsreformoftheOriginalBlac
4、kPlasterisreasonableandnecessary.Methods:1Qualityanalysisresearch:OThinlayerchromatography:TLCWasusedtoidentifyEphedra、ScutellariabaicalensisLeorgi、Leguminosae、CtednS{asinensisLam、Platycodongrandiflorum、DiascoreaNipponicaMak、Borneol,ArdisiajaponicainMa
5、qinjizhiPatch.②ThelimitedamountofAristolochicAcidAintheHerbaAsariwasdeterminatedbyTLC.③ThecontentsofEphedrineHydrochlorideandbaicalininMaqinjizhiPatchWasdeterminedbyHPLC,inwhichthechromatographyconditionswerethattheAgilentExtendC18(4.6mmx250mm,5J.tm)co
6、lumnWasused,themobile、,TTT②StudyonthelimitedamountofAristolochicAcidAhadshownthatthereisnotthesamespotofAristolochicAcidAontheTLCpictureoftheMaqinjizhiPatchandthemedicinalmaterials.TheminimumdetectablelevelofAristolochicAcidAwas0.031txg.③Thedetectionso
7、fEphedrineHydrochlorideshowedthattheirlinearrangwere0.0493I_tg7、一0.4930I_tg(r=O.9999)andO.054昭~0.54I_tg(r=O.9997);precision(RSD)were0.96%and1.48%;averagecontentsofEphedrineHydrochloridewere0.0790%(RSD=I.58%)and0.8352%(RSD=2.12%)inthereproducibilityexpe
8、riments;averagerecoverywere99.05%(RSD=2.51%)and98.12%(RSD=1.55%);respectively.ThecontentsofEphedrineHydrochlorideinthreebatchesWere2.976mg,3.200mg,2.940mgand33.40mg,32.00mg,33.40mgperpatch,respectively.唯。2StudyonComparisonofMaqinJizhiPa
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