麻芩急支膏贴与原黑膏药咳喘膏的质量分析与比较分析

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1、的薄层鉴别、有效成分的含量测定及离体小鼠透皮率、释放度的比较研究，论证了麻芩急支膏贴新剂型优于传统的黑膏药剂型，证实了黑膏药咳喘膏剂型改革的合理性和可行性。关键词麻芩急支膏贴；咳喘膏；薄层鉴别；含量测定；离体透皮率；释放度ⅥIStudyonQualityAnalysisandComparisonofMaqinJizhiPatchwithKechuanPlasterSpeciality：TheChineseMateriaMedicaAuthor：FangYouniTutor：HanJianweiObj

2、ective：Abstract’-^Throughtheanalyticalmethodsincludingthinlayerchromatography,contentdeterminationontheeffectiveingredientsinMaqinjizhiPatchandcomparedwiththeOriginalBlackPlasterfromthinlayerchromatography,contentdetermination，releaserate，vitropercutan

3、eousrate，whichhasconfirmedthereasonoftheclinicalcurativeeffectofMaqiniizhiPatchisbetterthanthatofOriginalBlackPlasterformthematerialbaseofdrug，releasespeedofdrugingredientsandthevitropercutaneousrate．IthasconfirmedtheformulationsreformoftheOriginalBlac

4、kPlasterisreasonableandnecessary．Methods：1Qualityanalysisresearch：OThinlayerchromatography：TLCWasusedtoidentifyEphedra、ScutellariabaicalensisLeorgi、Leguminosae、CtednS{asinensisLam、Platycodongrandiflorum、DiascoreaNipponicaMak、Borneol，ArdisiajaponicainMa

5、qinjizhiPatch．②ThelimitedamountofAristolochicAcidAintheHerbaAsariwasdeterminatedbyTLC．③ThecontentsofEphedrineHydrochlorideandbaicalininMaqinjizhiPatchWasdeterminedbyHPLC，inwhichthechromatographyconditionswerethattheAgilentExtendC18(4．6mmx250mm，5J．tm)co

6、lumnWasused，themobile、，TTT②StudyonthelimitedamountofAristolochicAcidAhadshownthatthereisnotthesamespotofAristolochicAcidAontheTLCpictureoftheMaqinjizhiPatchandthemedicinalmaterials．TheminimumdetectablelevelofAristolochicAcidAwas0．031txg．③Thedetectionso

7、fEphedrineHydrochlorideshowedthattheirlinearrangwere0．0493I_tg7、一0．4930I_tg(r=O．9999)andO．054昭～0．54I_tg(r=O．9997)；precision(RSD)were0．96％and1．48％；averagecontentsofEphedrineHydrochloridewere0．0790％(RSD=I．58％)and0．8352％(RSD=2．12％)inthereproducibilityexpe

8、riments；averagerecoverywere99．05％(RSD=2．51％)and98．12％(RSD=1．55％)；respectively．ThecontentsofEphedrineHydrochlorideinthreebatchesWere2．976mg，3．200mg，2．940mgand33．40mg，32．00mg，33．40mgperpatch，respectively．唯。2StudyonComparisonofMaqinJizhiPa