焦虑、抑郁对哮喘小鼠气道高反应和炎症的影响

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1、Abstractdepressiongroupwerehigherthanintheasthmagroup(allP<0．05)；theairwayhyperresponsivenessinasthmatreatmentgroupwere10werthanintheasthmagroup(allP

2、ayhyperresponsivenessinasthmadepressiontreatmentgroupwerelowerthanintheasthmadepressiongroupfallP<0．05)．3．AfterthemodelsinducedbyOVA，thetotalnumberofinflammatorycells，percentageofeosinophils，andthelevelsoflL-4，IL-13inthebronchoalveolarlavagefluidwerehigherthanthoseint

3、heothergroups(allP<0．05)．Thetotalnumberofinflammatorycells，percentageofeosinophils，andthelevelsofIL．4，IL．13inthebronchoalveolarlavagefluidofasthmaanxietygroupandasthmadepressiongroupwerehigherthanintheasthmagroup(allP<0．05)．Comparedwiththecontrolgroup．thetotalnumberof

4、inflammatorycells，percentageofeosinophils，andthelevelsofIL_4．IL一13inthebronchoalveolarlavagefluidoftheanxietyanddepressiongrouphavenosignificantdifferencefallP>0．05)．Intheasthmatreatmentgroupthetotalnumberofinflammatorycells，percentageofeosinophils，andthelevelsofIL．4，

5、IL一13inbronchoalveolarlavagefluidwerelowerthantheseinasthmagroup(all尸<0．05)．Intheasthmaanxietytreatmentgroupthetotalnumberofinflammatorycells，percentageofeosinophils，andthelevelsofIL-4，IL．13inbronchoalveolarlavagefluidwerelowerthantheseinasthmaanxietygroup(allP<0．05)．

6、Intheasthmadepressiontreatmentgroupthetotalnumberofinflammatorycells，percentageofeosinophils，andthelevelsofIL-4，IL一13inbronchoalveolarlavagefluidwerelowerthantheseinasthmadepressiongroup(all尺0．05)．SuccessfullyconstructedBALB／Cmicewereanxiety，depressionmodelinthisstudy

7、Conclusion1．TheanxietyanddepressionmodelCanbebuiltsucessfullybyBALB／cmouseinthisstudy；2．AnxietyanddepressioncanincreasetheairwayhyperresponsivenessandinflammationVIAbstract3．Anxiolyticandantidepressanttherapyhaveabenefitforthecontrolofasthmaairwayhyperresponsivenessan

8、dinflammation．keywords：Asthma；Anxiety；Depression；Airwayhyperresponsiveness；Airwayinflammation；MiceVII正文部分目录目录缩略语表⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯