早期盲人静息状态下局部脑活动分析

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1、天津医科火学硕十学何论文早期盲人静息状态下局部脑活动研究AbstractPurposeEarlyblindness嬲aunimodalsensorydeprivationmodelhasbeenextensivelystudiedbytask-basedfunctionalmagneticresonanceimaging．Recentlytworesting—statefMRIstudieshavereportedalteredfunctionalconnectivitybetwe饥visualandotherbrainareasinearlyblind，however,the

2、ycannotanswerwhichbrainareas’localactivitiesarechanged．Amplitudeoflow—frequencefluctuation(ALFF)andRegionalhomogeneity(ReHo)areallproposedbyZangetal，whichCanreflectspontaneousneuralactivity,havebecomemainindexestostudylocalbrainactivityinresting-state．Sofar,theyhavebeenusedtoinvestigatephysi

3、calstateandavarietyofbraindiseases，whicharepartlyconsistentwiththepathophysiologicalchangesinthesedisorders．Thereisnostudyonregionalbrainactivitychangesofearlyblindinresting—state．Inourstudy,weuseALFFandReHotoanalyzechangesoflocalbrainactivityinresting-state．MateralsandMethodsAlltogethersixt

4、eenearlyblindandthirty-twoage-andgender-matchedsightedsubjectsenrolledinourstudy．Resting-statefMRISCanandsagittalstructuralimageswereallcollectedusinga3．0一Tscanner．Allpreprocessingstepswerecarriedoutusingthestatisticalparametricmapping(SPM8，http：／／www．fil．ion．ucl．ac．uk／spm)，includingtimeslic

5、ing,reducingheadmovement，normalizedtotheMNI，resamplingto3x3x3mmcubicvoxels，aband—passfrequencyfilter(0．0l_o．08Hz，toreducelow一行equ伽cydriftandhigh-frequencynoise)，smoothedwitha6mmfullwidthathalfmaximum．TheunnormalizedandnormalizedALFFandReHovalueswerecalculatedusingspecificalgorithms，brainarea

6、swithsignificantchangesinALFForReHovaluesbetweengroupswereacquiredbyatwo-samplettest．TostudytherelationshipofbetweenALFFandtheunderlyingbloodoxygenlevel—dependent(BOLD)signals，wemeasuredtheactivityamplitude(AM)ofthewholebrainandfiveregionsofinterest(ROI)withsignificantlyincreasedALFFvaluesin

7、theearlyblindunderanormalizedmethod．AfterwegottheReHovalueofeveryvoxel，anindividualReHomapwasobtainedonavoxelbyVOXelbasisusingRESTsoftware．Toreducetheeffectofindividualvariance，wenormalizedtheRehovalueofeachvoxelbydividingthemeanRehoofthewholebrain