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ID:32138661
大小:1.42 MB
页数:46页
时间:2019-01-31
《哮喘患儿尘螨特异性免疫治疗前后过敏原变化与临床疗效分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、重庆医科大学硕士研究生学位论文因哮喘输液的天数与SIT前1年相比均有显著减少(P<0.0001),且两组之间比较亦有显著差异(P2、存在差异(P=O.067);不足3年疗程SIT组未完成3年疗程的原因,以好转停药和怀疑治疗效果为主,分别占36%和32%。结论3年足疗程SIT组较不足3年疗程SIT组能更加显著改善哮喘临床症状,有效的控制哮喘发作;在SIT治疗过程中加强健康教育等措施提高患儿及患儿家长的依从性,势必对哮喘的控制有积极的影响。关键词:儿童哮喘,特异性免疫治疗,依从性重庆医科大学硕士研究生学位论文ALLERGENSENSITIZATIONCHANGESANDCLINICALEFFECTOFASTHMATICCHILDRENWITHS3、TANDARDHOUSEDUSTMITESPECIFICIMMUNOTHERAPYABSTRACTPAI玎IALLERGENSENSITIZATIONCHANGESOFASTHMATICCHILDRENWITHSTANDARDHoUSEDUSTMITEEXTRACTSPECIFIC-IMMUNOTHERAPYObjectiveThisstudywasaimedtoanalyzetheallergensensitizationchangesofSkinPrickTests(SPT)inChildrenwithas4、thma,sensitizedtoHouseDustMite(HDM)orHDMincombinationwithotherallergensandacceptedstandardHDMSpecificImmunotherapy(SIT),researchtheeffectofchildrenwithasthmabystandardHDMSITfromallergensensitization.Methods140casesweremadeadefinitediagnosisaschildhoodasthma,5、SPT,atleastoneofthemites(Dermatophagoidespteronyssinus,Dermatophagoidesfarinae,Blomiatropicalis)manifestedskinindex(SI)“2+++",wererecruitedforthisstudy.SITwithstandarddustmiteextract,providedbydenishALK—ABELLOcorporation.Thecasesweredividedinto2groupsaccordi6、ngtoclinicalinvestigationtime:6monthsgroup(93cases)and12monthsgroup(78cases),3lcaseswererecheckedSPTafter6monthsand12monthsamongthetotal.13standardallergens6重庆医科大学硕士研究生学位论文liquorforSPT(providedbydenishA工,K_一ABELL0corporation)wereusedformeasuringthechangeofsk7、indiameterandatopynumbers(Dermatophagoidespteronyssinus,Dermatophagoidesfarinae,Blomiatropicalis,Blattellagermanica,Americancockroach,mouldmixI,mouldmixIV,Cathair,Doghair,PollenIV,PollenI,Mugwort,Ambrosiaartemisifolia)beforeSIT、after6monthsofSITand12monthsof8、SIT,tocomparetheSPTallergensensitizationresultsofprior-treatmentandpost—treatment.ResultsOftheall140cases,72.86%(103/140)wasHDM.monosensitized,62.85%(88/140)WassensitizedtoHDMincombinationwithot
2、存在差异(P=O.067);不足3年疗程SIT组未完成3年疗程的原因,以好转停药和怀疑治疗效果为主,分别占36%和32%。结论3年足疗程SIT组较不足3年疗程SIT组能更加显著改善哮喘临床症状,有效的控制哮喘发作;在SIT治疗过程中加强健康教育等措施提高患儿及患儿家长的依从性,势必对哮喘的控制有积极的影响。关键词:儿童哮喘,特异性免疫治疗,依从性重庆医科大学硕士研究生学位论文ALLERGENSENSITIZATIONCHANGESANDCLINICALEFFECTOFASTHMATICCHILDRENWITHS
3、TANDARDHOUSEDUSTMITESPECIFICIMMUNOTHERAPYABSTRACTPAI玎IALLERGENSENSITIZATIONCHANGESOFASTHMATICCHILDRENWITHSTANDARDHoUSEDUSTMITEEXTRACTSPECIFIC-IMMUNOTHERAPYObjectiveThisstudywasaimedtoanalyzetheallergensensitizationchangesofSkinPrickTests(SPT)inChildrenwithas
4、thma,sensitizedtoHouseDustMite(HDM)orHDMincombinationwithotherallergensandacceptedstandardHDMSpecificImmunotherapy(SIT),researchtheeffectofchildrenwithasthmabystandardHDMSITfromallergensensitization.Methods140casesweremadeadefinitediagnosisaschildhoodasthma,
5、SPT,atleastoneofthemites(Dermatophagoidespteronyssinus,Dermatophagoidesfarinae,Blomiatropicalis)manifestedskinindex(SI)“2+++",wererecruitedforthisstudy.SITwithstandarddustmiteextract,providedbydenishALK—ABELLOcorporation.Thecasesweredividedinto2groupsaccordi
6、ngtoclinicalinvestigationtime:6monthsgroup(93cases)and12monthsgroup(78cases),3lcaseswererecheckedSPTafter6monthsand12monthsamongthetotal.13standardallergens6重庆医科大学硕士研究生学位论文liquorforSPT(providedbydenishA工,K_一ABELL0corporation)wereusedformeasuringthechangeofsk
7、indiameterandatopynumbers(Dermatophagoidespteronyssinus,Dermatophagoidesfarinae,Blomiatropicalis,Blattellagermanica,Americancockroach,mouldmixI,mouldmixIV,Cathair,Doghair,PollenIV,PollenI,Mugwort,Ambrosiaartemisifolia)beforeSIT、after6monthsofSITand12monthsof
8、SIT,tocomparetheSPTallergensensitizationresultsofprior-treatmentandpost—treatment.ResultsOftheall140cases,72.86%(103/140)wasHDM.monosensitized,62.85%(88/140)WassensitizedtoHDMincombinationwithot
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