哮喘患儿尘螨特异性免疫治疗前后过敏原变化与临床疗效分析

《哮喘患儿尘螨特异性免疫治疗前后过敏原变化与临床疗效分析》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、重庆医科大学硕士研究生学位论文因哮喘输液的天数与SIT前1年相比均有显著减少(P<0．0001)，且两组之间比较亦有显著差异(P

2、存在差异(P=O．067)；不足3年疗程SIT组未完成3年疗程的原因，以好转停药和怀疑治疗效果为主，分别占36％和32％。结论3年足疗程SIT组较不足3年疗程SIT组能更加显著改善哮喘临床症状，有效的控制哮喘发作；在SIT治疗过程中加强健康教育等措施提高患儿及患儿家长的依从性，势必对哮喘的控制有积极的影响。关键词：儿童哮喘，特异性免疫治疗，依从性重庆医科大学硕士研究生学位论文ALLERGENSENSITIZATIONCHANGESANDCLINICALEFFECTOFASTHMATICCHILDRENWITHS

3、TANDARDHOUSEDUSTMITESPECIFICIMMUNOTHERAPYABSTRACTPAI玎IALLERGENSENSITIZATIONCHANGESOFASTHMATICCHILDRENWITHSTANDARDHoUSEDUSTMITEEXTRACTSPECIFIC-IMMUNOTHERAPYObjectiveThisstudywasaimedtoanalyzetheallergensensitizationchangesofSkinPrickTests(SPT)inChildrenwithas

4、thma，sensitizedtoHouseDustMite(HDM)orHDMincombinationwithotherallergensandacceptedstandardHDMSpecificImmunotherapy(SIT)，researchtheeffectofchildrenwithasthmabystandardHDMSITfromallergensensitization．Methods140casesweremadeadefinitediagnosisaschildhoodasthma，

5、SPT,atleastoneofthemites(Dermatophagoidespteronyssinus，Dermatophagoidesfarinae，Blomiatropicalis)manifestedskinindex(SI)“2+++"，wererecruitedforthisstudy．SITwithstandarddustmiteextract，providedbydenishALK—ABELLOcorporation．Thecasesweredividedinto2groupsaccordi

6、ngtoclinicalinvestigationtime：6monthsgroup(93cases)and12monthsgroup(78cases)，3lcaseswererecheckedSPTafter6monthsand12monthsamongthetotal．13standardallergens6重庆医科大学硕士研究生学位论文liquorforSPT(providedbydenishA工，K_一ABELL0corporation)wereusedformeasuringthechangeofsk

7、indiameterandatopynumbers(Dermatophagoidespteronyssinus，Dermatophagoidesfarinae，Blomiatropicalis，Blattellagermanica，Americancockroach，mouldmixI，mouldmixIV，Cathair，Doghair，PollenIV，PollenI，Mugwort，Ambrosiaartemisifolia)beforeSIT、after6monthsofSITand12monthsof

8、SIT，tocomparetheSPTallergensensitizationresultsofprior-treatmentandpost—treatment．ResultsOftheall140cases，72．86％(103／140)wasHDM．monosensitized，62．85％(88／140)WassensitizedtoHDMincombinationwithot