fish技术在宫颈癌和乳腺癌检测中的临床应用分析

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1、第三军医大学硕+学位论文主要英文缩写一览表英文缩写英文全称中文全称CINCervicalIntraepithelialNeoplasia宫颈上皮内瘤变CSPCentromereofchromosomeSpecialProbe染色体着丝粒探针DAPI4,6一diamidino-2一phenylindole4，6一二氨基一2．苯吲哚DFSDisease．freesurvival无病生存率FISHFluorescenceinSituHybridization荧光原位杂交GLPGenelocus．specialprobs位

2、点特异性探针HR-HPVHigh．riskhumanpapillomavirus高危型人类乳头瘤状病毒Her-2Humanepidermalgrowthfactorreceptor2人类表皮生长因子受体2HC-2HybridCaptureII杂交捕获法二代hTERCHumantelomeraseRNAgenecomponents人类端粒酶RNA基因组分hTERTHumantelomerasereversetranscriptase人类端粒酶逆转录酶ICCInvasiveCervicalCancer浸润性子宫颈癌ID

3、CInvasiveDuctalCarcinoma浸润性导管癌IHCImmunohistochemistry免疫组化NPVNegativePredictionValue阴性预测值OSOverallSurvival总生存率PCRPolymeraseChainReaction多聚酶链反应PPVPositivePredictionValue阳性预测值RTKReceptorTyrosineKinase受体酪氨酸激酶SeSensitivity敏感性SpSpecificity特异性TCTThin—prepCytologicalT

4、est薄层液基细胞学检测TBSTheBethesdaSystemforreportingcervical巴氏宫颈细胞学报告系统cytology第三军医人学硕十学位论文Fluorescenceinsituhybridization(FISH)fordetectionofcervixcancerandbreastcancer：aclinicalBackground_^●●·●researcll0I-aOOlicationAbstractCervixcancerandbreastcancerarefrequentgyne

5、cologicalmalignanttumorinrecentyears，theincidencesofwhichareonthetopinourcountry,withthetendencytoriseyearbyyear．Tothetreatmentandpreventionoftumors，theforemostprincipleisearlydiagnosisthenearlytreatment．Therefore，ontheprocessoftumorigenesisanddevelopment，thed

6、etectiontocytogeneticchanges，isanimportantmethodforearlydiagnosisandearlytreatmentoftumors，whichisofgreatsignificancetoimproveprognosisofpatientsandraiselifequality．Atpresent，theearlydiagnosisagainsttocervixcancer,mainlycontainscellmorphologyexamine，HPVvirusde

7、tection，andsomeothercommontumormarkerscreening．ThescreenforbreastcancerismainlyimageologicalexamineandIHCetc．Nevertheless，thetraditionalmethodscan’tsatisfythebothsideofsensitivityandspecificity．Fluorescenceinsituhybridization(FISH)isatechnologyconjunctofinsitu

8、molecularcytohybridizationandfluorescenttechnique，comparedwiththetraditionalcytogeneticaltechnique，whichhastheadvantagesofhighsensitivity,strongsignal，fast，convenienceandaccurateal