皮肤科患者糖皮质激素治疗对骨质代谢的影响因素分析

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1、浙江大学2007届硕士学位论文StudyofFactorsAssociatedWithBoneTurnoverinPatientsonGlucocorticoidTherapyinDermatologyDepartmentofDermatologyandVenerologyMedicalSchoolofZhejiangUniversityPostgraduate：WuDa-xingTutor：YuHai-yanAbstractObjective：Todemonstratetheriskfactorsofglucocorticoid-inducedbonelossandtheir∞lafi

2、vesignifieancoindermatologypatients,investigatetheprophylaxissituationofglucocorticoid-inducedosteoporosis，andftlrthel"evaluatetheclinicaleffectsonbonelossofprophylaxispathwayforglucocorticoid-inducedosteoporosisindermatologydepartment．Me恤ods：(1)11lemedicalrecordsof63casespatientsinSirRunShawHosp

3、italofZhejiangUniversityfromJanuary2004toApril2007w啪reviewed,andtheoorrelationsofpatients’gender,age，glucocorticoidaccumulativedoseandtherapydurationetalwithpatients’BMDwereanalyzedbyusingmultiplelinerregressionanalysisandBivariatecorrelationanalysis．(2)73Casesofsystemiclup鹕erythematosusandanaphy

4、lactoidpurpurainpatients’clinicaldatafromJanuary2004toMarch2006indermatologydepartmentwerereviewed．PatientsrequiringtreatmentwithatleastlOmg／ddosesofprednisone(orequivalent)formomthan3monthswereincludedinthisretrospectivestudy．TheoutputsofBMDinvestigationandthemonitoringandprophylaxissituationofg

5、lucocorticoid-inducedosteoporosiswereinvestigated．4浙江大学2007届硕士学位论文(3)FromMay2006，allinpatientsreceivingglucocorticoidtherapyformorethan3months01"prospectedformol'ethan3monthshadtheirbaselinebonemineraldensity(BMDlinvestigatedafterhospitalization,anddataregardingtheuseofghicocorticoid,osteoporosis

6、prophylaxisandmonitoringWerealsocollectedandcomparedwiththeretrospectivedata．Aprospectiveself-enntrolclinicaltrialwasconductedtostudytheeffectofalendronateintearingpatientswithdecreasedBMDafteradministrationfor3and6months．Result：(1)mskfactorsofghicocorticoid-inducedbonelosswereasfollows：MUltiplel

7、inerregressionanalysisandBivariatecorrelateanalysisshowedthatamongpatientswhoreceivedghicocorticoidtherapylessthan12months，theagesandaccumulativeglneocorticoiddoseswerenegativelycorrelatedtopatients’BMDoflumberspine，Pe