通心络对局灶性脑缺血大鼠微血管新生与其代偿作用的实验-.研究

《通心络对局灶性脑缺血大鼠微血管新生与其代偿作用的实验-.研究》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、英文摘要ExperimentalstudyontheinterVentionalefl’ectsof1’0ngxinluoonangiogenesisandcompensatoryfunctionafterfocalcerebral●■lSCnemlaABSTRACTobjective：Inthisstudy，directedbycollateraldiseasetheo拶，usingcraniotomy1igationasideofthemiddlecerebralane巧establishedthemodeloffocalcerebralisc

2、hemia．1bexploreen’ectiVelytherapeutic如nctiononneurologicalrecoVe巧ofischemicstroke，wechoseitsrepresentatiVeprescription：Tongxinluo，andobserveditsimerventionaleffectsonbehaVioralscoring，mo叩h0109yofbraintissue，microVasculardensi吼diameterandvolumesofbloodpermsion，relatedangiogenes

3、isfactorsandtheirexpression．Theresultswouldbehelp如lfor如rtherproVidingexperimentalsupportforscientincvalueofcollateraldiseasetheoWinischemiccerebroVasculardisease．Methods：1Thee位ctsofTongxinluooninf．arctionareaandneurologicalbehaVioroff．ocalcerebralischemiaratsFocalcerebralische

4、miamodelwasdevelopedwithmaleSDratsofhealthSPFgrade．TheanimalswererandomlydiVidedintosixgroups：theshamgroup，themodelgroup，Tong)【inluohi曲一dose(2．49／l(g。d)黟oup，middle．dose(1．29／kg·d)group，10w-dose(O．69／kg·d)groupandthenimodipine(1Omg／1喝·d)group．Usingcraniotomyligationasideofthemi

5、ddlecerebralarteryestablishedthemodeloffocalcerebralischemia．Shamgroupwasonlypushedasidemeninges，notligationVascular．Allgroupswereirrigated，besidessh锄groupandmodel铲．oupweregaveisotonicNachloride．TheneachgroupwasdiVidedintothreetimepoints：3d，7dand14d(n。6)．PosturalI沁nexTest，Fore

6、limbMuscleStrengthTestandBeamWalkingTestwereusedforneur0109icalbehaviorgrading．HEstainingwasusedtodetectthehistomo印hologicalchangesofbraintissueandTTCStainingwasusedto5英文摘要calculatetheproportionofcerebralinf打ction2urea．2TheeffectsofTongxinluoonmicrovasculardensi吼di啪eterandVolu

7、mesofbloodper如sionGroupingandmodelingidem．Microvasculardensityofcerebralcortexischemiaareawastestedthrou曲immunohistochemicalkitat14daRerheartpermsionfixation．MicroVasculardiameter，mo巾hologyandvolumesofplasmapermsionofcerebralmicroVessels，throughfemoralVeinbeingper如sedwithFITC—

8、deXtran，wereanalyzedwimlightmicroscope(40times)at14daRerfocal