可逆加成.断裂链转移自由基聚合制备分子印迹微球

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1、Abstract_I一--●_-__—●-_——-——_—●__●_---_—————_———-●__--l—_-—●—●-●l_-—-●I—●_●I_—__—_--’—__I—Thisdissertationconsistsoffourchapters：(1)AreviewofMolecularImprintingTechnology(MIT)andreversibleaddition—fragmentationchaintransferpolymerization(RAFTpolymerization)

2、．(2)ThesynthesisandpurificationoftheRAFTreagent-cumyldithiobenzoate(CDB)．(3)Thestudyonthepreparationofmolecularlyimprintedpolymermicro-spherical(MIPMS)byRAFl’-precipitationpolymerization．(4)TheprimarystudyOilseparationandextractionofenrofloxacinfrombiologi

3、calsample(eggs)byusingMIPMS．(5)Conclusionandprospectoftheresearch．Chapter1consistedofaintroductionofmolecularImprintingTechnologyandreversibleaddition．fragmentationchaintransferpolymerization．Thediscussionincludedthemechanisms，synthesismethods，characterist

4、icproperties．Theapplicationsofmolecularlyimprintedpolymers(MIPs)andfurtherresearchwerealsopresented．Inchapter2，thesyntheticmethodandtheprocessofpurificationforthereagentRAFT(cumyldithiobenzoate)weredescribed．Syntheticconditionswereoptimized．Thetargetcompou

5、ndwasobtainedbycolumnchromatographicseparation．Inchapter3，themethodofusingoneliving／ControlledRadicalpolymerization(reversibleaddition．fragmentationchaintransferradicalpolymerization，RAFTpolymerization)forthesynthesisofmolecularlyimprintedmicrospherewasdev

6、eloped．Thepolymericmicrospheresweresynthesizedbyprecipitationpolymerizationwithacetonitrileasthedispersant,enrofloxacinasthetemplate，methyacrylicacid(MAA)嬲thefunctionalmonomer，ethylenedimethacrylate(EDMA)asthecrosslinker，cumyldithiobermoate(CDB)astlleRAFTa

7、gentandazobisisobutyronitrile嬲theinitiator．TheresultsindicatedthepolymericmicrospheressynthesizedwithRAFTpolymerizationhavediameterof2．0—2．2pmandbetterparticlesizedistribution．TheequilibriumadsorptionexperimentshowedthattheMIPMShaverecognitionpropertyforth

8、etemplatemolecule．5Abstract———————————-—————————————————————————————————’———————————————一一Inchapter4，themethodfortheseparationandextractionofenrofloxacinbyMIPMSfromeggswasresearched．TheresultshowedtheMIPMShay