复方绞股蓝颗粒对慢性脑缺血大鼠脑内氧化应激反应影响

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1、学校代码：10600学号：2005051学号：05051广西中医学院医学硕士专业学位论文复方绞股蓝颗粒对慢性脑缺血大鼠脑内氧化应激反应的影响研究生:徐昭导师:黄立武主任医师院系(部所):第一临床医学院专业:中医内科学研究方向:中医药防治脑血管病的临床研究完成日期:2008年4月20日目录中文摘要···············································1英文摘要···············································3引言··········································

2、······6正文················································91.材料及方法··········································91.1实验动物·············································91.2主要仪器设备及其来源·································91.3主要试剂············································91．4药物···························

3、·····················91．5动物模型制备及分组··································101．6干预方法············································101．7观察指标············································111．8统计学分析··········································132．结果·················································132.1大鼠一般情况

4、观察································132.2行为学检测··········································132.3MDA、SOD、NO实验结果································142.4各组脑缺血大鼠脑内MDA的变化························152.5各组脑缺血大鼠脑内SOD的变化························152.6各组脑缺血大鼠脑内NO的变化·························152.7大鼠脑组织病理结果·········

5、··························163．讨论················································163.1现代医学对慢性脑缺血的认识··························163.2中医对慢性脑缺血的认识······························173.3复方绞股蓝颗粒的组成及功效··························183.4复方绞股蓝颗粒防治慢性脑缺血的作用··················193.5复方绞股蓝颗粒的展望·······················

6、·········21结论··············································23参考文献··············································24综述··············································27致谢··············································34攻读学位期间发表的学术论文目录···················35作者声明·······································

7、·······36个人简历··············································37中文摘要目的：观察复方绞股蓝颗粒对慢性脑缺血大鼠脑内氧化应激反应的影响方法：采用永久性双侧颈总动脉结扎术（２vo）制备40只大鼠慢性脑缺血的动物模型，按数字随即表分为4组，即假手术组、模型组、中药复方绞股蓝组、西药尼莫地平组，通过免疫组化分析，酶活性测定等，观察复方绞股蓝颗粒对大鼠脑内的MDA、NO、SOD等指标，针对其中药方剂的功效和作用特点，在原有的研究基础上从氧化应