表面改性羟基磷灰石纳米杂化粒子与复合材料的制备与表征

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1、摘要的调节，制备了Gel／HA@Gel复合纳米纤维和PLL～Gel／H[A@Gel三组分复合纳米纤维。相对于未改性nHA，表面接枝改性的nHA在纤维中分散性明显改善。通过上述研究，本论文提供了一种基于ATI冲对nHA进行表面接枝改性的方法，并通过复合材料的制备验证了接枝改性对于提高纳米无机粒子在聚合物基体中分散性的可能性，为制备具有更优性能的骨再生修复材料提供了参考。关键词：羟基磷灰石，原子自由基转移聚合，聚乳酸，明胶，静电纺丝北京化工大学硕：}：学位论文PREPARATIoNANDCHARACTEIUZ

2、ATIoNoFSURFACEMoDIFIEDHYDRoXYAPATITENANoHYRIDSANDCoMPoSITESABSTRACTTheartificialsynthesizednanohydroxyapatite(nHA)filledbi()degrad百blepolymerconlpositeiswidelyusedintheareaofbonetissueengineeringduetoitsverysimilari叫onthe·chemicalcompositionandstlllcturet

3、othenaturalhydroxyapatite(HA)inthebones．HoweVer，becauseoftheeas订yaggregationofthenHAinthep01ymermatrix，itisimportanttoimproVethec()mpatibilityofHAnanoparticlesinbiodegradablepolymerstoobtaindesir￡Iblenanocompositesforbonetissueengineeringapplications．Inor

4、dertoimprovethedispersionofnHAinPoly(L—LactiIde)(PLLA)matrix，inthispaper，HAw’iththederiVedATRPinitiatorswasobtainedbypr印arationofHAfromprecursorsinthepresenceof3-aminopropyl一triethoxysilane(APTS)toproducetheHA吼lrfacewithterminal一NH2groups(HA—NH2)andreacti

5、onofthe-NH2gr()upsoftheHA—NH2nanoparticleswith2_bromoisobutyrylbromide(BIBB)toproducethe2-bromoisobutyryl一imm()bilizednanoparticles(HA—Br)．TheHA@PGMAandHA@PHEMAnanohy]bridsweresynthesizedthatthep01y(91ycidyllVmethacrylate)(PGMA)andthep01y(2_hydroxyeth姐met

6、hac巧late)(PHEMA)weregraRedf-romthesurfaceofnHAViaatomstransferradicalpolymerization(ATRP)，respectiVely．TheHA@PGMA—g’PLLAnanohybridsweregainedthrough‘‘GraRto’’methodthattheca而oxyl—tenninatedP01y(L—Lide)(PLLA．COOH)wasattachedontoHA@PGMAontothesurfaceofHAvia

7、reactionbetweenend—groups．W11ile，thehydroxylsontheHA@PHEMAsurfacewereusedtoinitiatetheringopeningpolymerizationofL一1actidetofomtheHA@PHEMA—g—PLLAnanohybridsby“GraR仔om”method．AnalysisincludingFTIR，XRD，TGA，DSC，SEMandTEMareusedtoprovethesuccess如1synthesisofd

8、ifIferentnanohybrids．Unexpectedly；theI．eweresomedisadvantagesinthesetwowaystoobtainPLLAgraRedHA．Inthefomer，althoughitwasgoodatcontr01ofattachedPLLAchain1ength，someoffinalHA@PGMA—g—PLLAdemonstratedinferiors01hbilityi