不同治疗方案对肝癌患者外周血afpmrna的影响与其与肝癌转移的关系

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1、ChangesofQ—fetoproteinmRNAinPeripheralBloodofPatientswithHepatocellularCarcinomaTreatedbyDifferentTreatmentMethodsandItsRelationshiptoMetastasisofHCCAbstractManystudieshaveconfirmedthathematogenousspreadmaybeamainpathforhepatocellularcarcinoma(HCC)metastasisandhepat

2、ocellularcarcinomastreatmenthasmanydimculties．ItiSthemaincausethatthehematogenousspreadormetastasisofHCCcarlnotbedetectedoutbeforeoperation，radiotherapyandchemotherapy．BecauseHCCcellmayivastintoperipheralblood，thedetectionofceilsofHCCinperipheralbloodhasveryhighvalu

3、efordeterminationofhematogenousspreadormetastasis．Accordingtomanystudiesaboutthe口一fetoproteinmRNA(AFPmRNA)inperipheralbloodofpatientswithHCC，weinvestigatedtheeffectofthreedifferenttreatmentmethodsontheAFPmRNAinperipheralofpatientswithHCCbvNested—RT-PCR．Theresultssho

4、wedthatthepositiverateofAFPmRNAinthepatientswitllHCCwas38．4％．buttherewasnotonepositivecaseinbenignliverdiseasesandhealthydonors，andaftertreatment，thepositiverateofAFPmRNAinthegrouptranscatherarenrialchemoembolization(A)andthegroupofstereotacticradiotherapy(B)washigh

5、erthanthatbeforetreatment(p

6、ashigherthanthatofC，andtherateofAandBfrompositivetonegativewaslowerthanthatofthenegative．InthepatientswhoseAFPmRNAinperipheralbloodwaspositive．therateofmetastasiswashi【gherthanthatofC．TheresultsuggestedthatAFPmRNAinperipheralbloodofpatientswithHCCwasrelatedtohematog

7、enousspreadingmetastasis．AFPmRNAexpressioninperipheralbloodactsaspredictivemarkerformetastasisofHCC．Keywords：Nested·RT-PCR；hepatocel!ulacarcinoma；cc．fetoproteinmRNA；metastasis；treatmentmethod：movablechange；prediction；elincialobervation．5J不同治疗方寒对肝癌患者外周血AFP删妣～的影响及其与肝癌

8、转移的关系月lJ吾肝细胞癌是我国常见的恶性肿瘤之一，手术切除虽是目前治疗肝癌的首选方法，但就肝癌总体而言，手术切除率低，复发率高。高复发率的原因是手术或放、化疗前存在未检出的微小转移灶或肿瘤细胞入血。因此早期发现外周血的肿瘤细胞，不仅对判断肝癌的转移、复发具有重要价值，而且对