对严重创伤失血患者进行镇静治疗应用研究

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1、对严重创伤失血患者进行镇静治疗应用研［摘要］目的研究对严重创伤失血性患者进行镇静治疗的应用效果和安全性。方法选择2009年7月〜2012年8月期间32例给予异丙酚镇静治疗的严重创伤失血患者作为观察组；另选择同期收治的29例接受常规治疗的严重创伤失血患者作为对照组，观察两组患者48h内的生命体征、重要脏器指标、应激水平以及免疫功能情况。结果两组患者一般资料无显著差异，两组患者治疗后的HR和MAP均得到明显改善，而观察组患者24h的HR显著低于对照组,6h的MAP显著高于对照组；两组患者治疗后的ALT和Cr均明显下降，而观察组患者48h的ALT显著低于对照组；两组患

2、者治疗后的NE和Cor均明显降低，观察组患者24、48h的NE和48h的Cor均显著低于对照组；两组患者治疗后的Glu明显降低，观察组治疗后6h的Glu显著低于对照组。结论严重创伤失血患者早期可能出现应激反应以及重要脏器功能异常，镇静治疗可以有效调节应激反应，从而达到保护脏器功能，提高疗效的作用。［关键词］严重创伤；失血；镇静；异丙酚；应激反应［中图分类号］R641［文献标识码］B［文章编号］1673-9701(2013)36-0149-03Applicationanalysisofsedationtherapyonseveretraumatichemorrha

3、gicpatientsJIBolWANGLiminlWANGJielianglHongXiaozhen21.EmergencyCenter,XinchangCountyPeople'sHospitalinZhejiangProvince,Xinchang312500,China；2.DiseasePreventionControlCenterofZhejiangProvince,Hangzhou310051,China[Abstract]ObjectiveTostudytheappliedeffectandsafetyofsedationtherapyonsev

4、eretraumatichemorrhagicpatients.MethodsThirty-twopatientswithseveretraumatichemorrhagereceivingpropofolsedationtherapyfromJuly2009toAugust2012wereselectedasobservationgroup,another29patientswithseveretraumatichemorrhagereceivingconventionaltherapywereselectedascontrolgroup・Thevitalsi

5、gns,importantorganindexes,stresslevelandimmunefunctionsofpatientsbetweentwogroupswereobservedandcomparedwithin48h・ResultsThegeneralclinicaldatehadnosignificantdifferenceintwogroups,bothHRandMAPinallpatientsimprovedsignificantlyaftertreatment,whereastheHRafter24hintheobservationgroupw

6、assignificantlylowerthanthatofcontrolgroup,butMAPafter6hwasobviouslyhigherthanthatofcontrolgroup・TheALTandCroftwogroupssignificantlydecreasedaftertreatment,whiletheALTafter48hintheobservationgroupwassignificantlylowerthanthatinthecontrolgroup.BothNEandCorconspicuouslydecreasedaftertr

7、eatment，whiletheNElevelafter24hand48handCorlevelafter48hweresignificantlylowerthanthoseinthecontrolgroup，whileGluintwogroupssignificantlydecreasedaftertreatment,andGluintheobservationgroupwassignificantlylowerthanthatincontrolgroupafter6h.ConclusionStressresponseandvitalorgandysfunct

8、ionmayoccuri