enzyme kinetics for systems biology_0982477317enzyme

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1、EnzymeKineticsforSystemsBiologyHerbertM.SauroUniversityofWashingtonSeattle,WAAmbrosiusPublishingCopyright©2009-2011HerbertM.Sauro.Allrightsreserved.FirstEdition,version1.01PublishedbyAmbrosiusPublishingandFutureSkillSoftwarewww.analogmachine.orgTypesetusingLATEX2",TikZ,PGFPlots,WinEdtan

2、d11ptMathTimeProfessional2FontsLimitofLiability/DisclaimerofWarranty:Whiletheauthorhasusedhisbesteffortsinpreparingthisbook,hemakesnorepresentationsorwarrantieswithre-specttotheaccuracyorcompletenessofthecontentsofthisbookandspecificallydisclaimanyimpliedwarrantiesofmerchantabilityorfitne

3、ssforaparticularpur-pose.Theadviceandstrategiescontainedhereinmaynotbesuitableforyoursituation.Neithertheauthornorpublishershallbeliableforanylossofprofitoranyothercommercialdamages,includingbutnotlimitedtospecial,incidental,consequential,orotherdamages.Nopartofthisbookmaybereproducedbya

4、nymeanswithoutwrittenpermissionoftheauthor.ISBN10:0-9824-7730-9(ebook)ISBN13:978-0-9824773-0-4(ebook)ISBN10:0-9824773-1-7(paperback)ISBN13:978-0-9824773-1-1(paperback)PrintedintheUnitedStatesofAmerica.MosaicimagemodifiedfromDanielSteger’sTikzimage(http://www.texample.net/tikz/examples/mo

5、saic-from-pompeii/ProteinimagesusedinmaintextfromRCSBProteinDataBankandDavidGoodsell©(www.pdb.org).Front-Cover:MetabolicpathwayimagefromJWSonline(JackySnoep)withpermission.ThepathwaydepictstheglycolyticpathwayfromLac-tococcuslactisusingtheSystemsBiologyGraphicalNotation(SBGN).Ref:Hoefna

6、gel,HugenholtzandSnoep,2002,TimedependentresponsesofglycolyticintermediatesinadetailedglycolyticmodelofLactococcuslactisduringglucoserun-outexperiments.Mol.Biol.Reports29,157-161ContentsPreface...............................viii1ReactionKinetics11.1RatesofChange......................41.

7、2ElementaryRateKinetics.................121.3ChemicalEquilibrium...................161.4KineticsacrossMembranes................251.5TemperatureDependence.................27ChapterHighlights........................29FurtherReading..........................31Exercises............