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ID:31538212
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页数:38页
时间:2019-01-13
《target site selection in transposition》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、P1:NBLMay6,19979:17AnnualReviewsAR032-15AR032-15Annu.Rev.Biochem.1997.66:437–74Copyrightc1997byAnnualReviewsInc.AllrightsreservedTARGETSITESELECTIONINTRANSPOSITIONNancyL.CraigHowardHughesMedicalInstitute,DepartmentofMolecularBiologyandGenetics,JohnsHopkinsUniversitySchoolofMedicine,Baltimor
2、e,Maryland21205KEYWORDS:integration,site-specific,non-LTRelement,retrovirus,transposonABSTRACTTransposableelementsarediscretemobileDNAsegmentsthatcaninsertintonon-homologoustargetsites.Diversepatternsoftargetsiteselectivityareobserved:Someelementsdisplayconsiderabletargetsiteselectivityandot
3、hersdisplaylit-tleobviousselectivity,althoughnoneappearstobetruly“random.”Avarietyofmechanismsfortargetsiteselectionareused:Someelementsusedirectinterac-tionsbetweentherecombinaseandtargetDNAwhereasotherelementsdependuponinteractionswithaccessoryproteinsthatcommunicatebothwiththetargetDNAan
4、dtherecombinase.Thestudyoftargetsiteselectivityisusefulinprobingrecombinationmechanisms,instudyinggenomestructureandfunction,andalsoinprovidingtoolsforgenomemanipulation.CONTENTSINTRODUCTION:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::438TargetSiteSelection:HowandWhen:::::::::
5、::::::::::::::::::::::::::::::::439TranspositionCanOccurbySeveralDifferentMechanisms::::::::::::::::::::::::440byUniversityofArizonaLibraryon07/22/11.Forpersonaluseonly.TRANSPOSITIONBYDNABREAKAGEANDJOINING::::::::::::::::::::::::::441TheMechanism:::::::::::::::::::::::::::::::::::::::::::::
6、:::::::::::::441TargetSelectionbytheInteractionofTransposasewiththeTargetDNA::::::::::::::444Annu.Rev.Biochem.1997.66:437-474.Downloadedfromwww.annualreviews.orgSelectingaTargetSiteThroughTransposaseInteractionwithAccessoryProteins::::::448Tn7CanBeAttractedtoReplicatingDNA::::::::::::::::::
7、:::::::::::::::::::452DiscouragingTransposonInsertionbyTargetTranscription:::::::::::::::::::::::453IntermolecularvsIntramolecularTransposition:ChannelingofTn10toPromotetheFormationofNewElements::::::::::::::::::::::::::::::::::454LocalHoppinginFliesandP
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