资源描述：
《临床医学毕业论文多西他赛同步放、化疗治疗局部晚期鼻咽癌的疗效观察》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、XX大学毕业论文多西他赛同步放、化疗治疗局部晚期鼻咽癌的疗效观察姓名：2014年6月25日作者：陈群，丁纯志，赵景胜，徐朝久,涂向阳，龙剑，向志碧【关键词】鼻咽癌；同步放化疗；多西他赛；疗效；毒副作用［摘要］目的：观察多西他赛同步放、化疗治疗晚期鼻咽癌的临床疗效和毒副作用，方法:132例局部晚期鼻咽癌患者随机分为两组，一组66例为多西他赛同步化疗+放疗(治疗组)，另一组66例为PF(DDP+5FU)方案同步化疗+放疗(对照组)。结果：在放疗肿瘤量DT50Gy吋治疗组鼻咽病灶消退率、颈部转移灶消退率分别为65.2%、69.7%,对照组分别为59」％、63.6%(P>0.0
2、5)。全程放疗结束后3个月治疗组鼻咽病灶消退率、颈部转移灶消退率分别为95.5%、93.9%,对照组分别为87.8%、86.4%(P>0.05)。中位随访35个月(11个月〜60个月),3a总生存率、屮位生存时间治疗组为81.9%.53个月，对照组为75.3%、52个月(P>0.05),3a无进展生存率及中位无进展生存吋间治疗组为70.2%、40月，对照组为64.0%、39个月(P>0.05)o3a局部控制率、中位无复发生存期分别是76.5%、52个月和70.7%、45个月(P>0.05)。对照组的毒副作用如恶心、呕吐、骨髓抑制均较治疗组明显，差异有显著性(PV0.05
3、)。结论：多西他赛同步放化疗与PF方案同步放化疗治疗晚期鼻咽癌,生存率及局部控制率相近,前者毒副作用较轻。［关键词］鼻咽癌；同步放化疗；多西他赛；疗效；毒副作用ConcurrentRadiotherapyandChemotherapywithDocetaxelForLocaladvancedNasopharyngealCarcinomaAbstract：ObjectiveToevaluatetheefficacyandsideeflectsofconcurrentradiotherapyandchemotherapywithDocetaxelforlocaladvanc
4、ednasopharyngealcarcinoma(NPC).Mcthods132patientswithlocaladvanccdNPCwererandomizedintotwogroups:66casesintreatmentgroupweretreatedconcurrentradiotherapyandchemotherapy(CCRT)withDocetaxelwhereas66casesincontrolgroupreceivedCCRTwithPF(cisplatinandfluorouracil).ResultsThedoseofradiationwas
5、50Gray(Gy)thenasopharyngeallesionremissionrateandcervicalmetastasisremissionratewere65.2%,69.7%intreatmentgroupand59」%,63.6%incontrolgroup(P>0.05).3monthsafterradiotherapythenasopharyngeallesionremissionrateandcervicalmetastasisremissionratewere95.5%,98.5%intreatmentgroupand87.8%,86.4%in
6、controlgroup(P>0.05).Withamedianfollowupof35months(rangfrom1160months),theoverallsurvivalrateat3yearwas81.9%,themediansurvivaltimewas53monthsintreatmentgroup,whereasincontrolgrouptheywere75.3%,52monthsrespectively(P>0.05)・The3yearprogressfreesurvivalrateandmedianprogressfi*eesurvivaltime
7、was70.2%,40monthsintreatmentgroupand64.0%,39monthsincontrolgroup(P>0.05).The3yearlocoregionalcontrolrateandmedianrelapsefreesurvivaltimewere75.6%,52monthsintreatmentgroupand70.7%,45monthsincontrolgroup(P>0.05).Sidccffcctssuchasnausac,vomitandmyclosupprcssionweremoresevere
