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1、NihonJinzoGakkaiShi.2013;55(4):567-73.[Acaseofcrescenticpoststreptococcalacuteglomerulonephritis(PSAGN)accompaniedbymembranousnephropathy].[ArticleinJapanese]MatsudaJ,NagayamaI,YamaguchiY,ItanoS,MoriD,ImakitaN,TakejiM,YamauchiA.SourceDepartmentofGeriatricMedicineandNephrol
2、ogy,OsakaUniversityGraduateSchoolofMedicine,Osaka,Tokyo.AbstractIn2010,a71-year-oldmanwasreferredtoourhospitalbecauseofmildproteinuriaandhematuria.Atthattime,hehadbeenasymptomatic.Threemonthslaterhenoticedmacroscopichematuria,followedbygeneralmalaise,andthenanorexia.Hewasa
3、dmittedforacutekidneyinjury(serumcreatinine2.7mg/dL),markedproteinuria(4.35g/gCr),andelevatedC-reactiveprotein(7.21mg/dL).Somevesicleswerenotedonthesoftpalate,andathroatcultureyieldedagrowthofgroupAbeta-hemolyticstreptococci.AntistreptolysinOandantistreptokinasetitersweree
4、levated,butserumcomplementlevelswerewithinnormallimits.Antineutrophilcytoplasmicantibodies(ANCA)directedagainstelastaseandbactericidalpermeabilityincreasingprotein(BPI)werepositive.Therenalfunctionandinflammationdidnotimprovedespiteoralantibiotictherapy.Pathologicalexamina
5、tionofarenalbiopsyspecimenrevealeddiffusecrescentformation,numeroussubepithelialdome-shapeddeposits(humps),andprominentendocapillaryproliferation.Furthermore,afocalandsegmentalspikeappearancewasseen,withdepositssmallerthanhumps.Therewasastrikingclinicalimprovementafterster
6、oidpulsetherapyfollowedbyoralprednisolone.ThefeaturesofthiscasestronglysuggestcrescenticPSAGNaccompaniedbypre-existingmembranousnephropathy.KidneyInt.2013Aug;84(2):366-72.doi:10.1038/ki.2013.55.Epub2013Feb27.Plasmasolubleurokinasereceptorlevelsareincreasedbutdonotdistingui
7、shprimaryfromsecondaryfocalsegmentalglomerulosclerosis.HuangJ,LiuG,ZhangYM,CuiZ,WangF,LiuXJ,ChuR,ChenY,ZhaoMH.Source1]RenalDivision,PekingUniversityFirstHospital,Beijing,People'sRepublicofChina[2]InstituteofNephrology,PekingUniversity,Beijing,People'sRepublicofChina[3]KeyL
8、aboratoryofRenalDisease,MinistryofHealthofChina,Beijing,People'sRepublicofChina[4]KeyLabo
