急性脑梗死患者尿酸水平及其相关危险因素的临床研究

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1、急者^X平;因麹1缽开究2018-03-2712:00:30中国现代医生2018年3期付新征饶华强任周明［摘要］目的探讨急性脑梗死患者与非脑梗死患者血清尿酸水平及相关危险因素的差异。方法收集2015年1月〜2017年6月在我院内科住院的患者共360例，其屮急性脑梗死患者180例，非脑梗死患者180例，检测360例的血淸尿酸水平及其相关危险因素。结果急性脑梗死组患者血淸尿酸水平(P=0.01)、颈动脉斑块例数(P=0.00)、收缩压(P=0.00)、舒张压(P=0.00)、总胆固醇(P=0.01)、低密度脂蛋白(P=0.00)、踝臂指数(P=0.01)与对照组比较有显

2、著差异。进一步调整尿酸、收缩压、舒张压、踝臂指数、总胆固醇、低密度脂蛋白等危险因素后，尿酸与急性脑梗死独立相关，与急性脑梗死独立相关的危险因索还有收缩压、低密度脂蛋白、踝臂指数。结论高尿酸是急性脑梗死患者的重要危险因素。尿酸与急性脑梗死独立相关，与急性脑梗死独立相关的危险因素还有收缩压、低密度脂蛋口、踝臂指数。［关键词］脑梗死；尿酸；颈动脉；动脉粥样硬化［中图分类号］R743.3［文献标识码］A［文章编号］1673・9701(2018)03-0026-04Clinicalstudyofuricacidlevelinpatientswithacutecerebrali

3、nfarctionandit'srelatedriskfactorsFUXinzhengRaoHuaqiangRENZhoumingDepartmentofNeurology,HainingPeople'sHospitalinZhejiangProvinee,Haining314400,China［Abstract］ObjectiveToinvestigatethedifferencesofserumuricacidlevelsandrelatedriskfactorsbetweenpatientswithacutecerebralinfaretionandthos

4、ewithoutcerebralinfarction.MethodsAtotalof360inpatientsadmittedinthedepartmentofinternalmedicineinourhospitalfromJanuary2015toJune2017wererecruited.180casesofthe360patientshadacutecerebralinfarctionand180casesdidnthavecerebralinfarction.Thelevelofserumuricacidanditsassociatedriskfactor

5、inthepatientsweredetected・ResultsThereweresignificantdifferencesinthelevelsofserumuricacid(P=0.01),carotidarteryplaque(P=0.00),systolicbloodpressure(P=0.00),diastolicbloodpressure(P=0.00),totalcholesterol(P=0.01),low-densitylipoprotein(P=0.00),ankle-brachialindex(P=0.01)betweentheacute

6、cerebralinfarctiongroupandthecontrolgroup・Afterfurtheradjustmentoftheriskfactorsincludinguricacid,systolicbloodpressure,diastolicbloodpressureriskfactors,ankle-brachialindex,totalcholesterolandlow-densitylipoprotein,uricacidwasindependentlyassociatedwithacutecerebralinfarction.Otherind

7、ependentriskfactorsassociatedwithacutecerebralinfarctionincludedsystolicbloodpressure,lowdensitylipoprotein,anklebrachialindex.ConclusionHyperuricemiaisanimportantriskfactorinpatientswithacutecerebsralinfarction.Uricacidisindependentlyassociatedwithacutecerebralinfarction.Otherriskfa