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1、帕瑞昔布超前镇痛在门诊无痛膀胱镜检查中的应用南京医科大学第二附属医院麻醉科210011【摘要】目的探讨帕瑞昔布超前镇痛在门诊无痛膀胱镜检查中的应用效果。方法选择100例行无痛膀胱镜检查的患者,随机分为两组:单纯丙泊酚组(N组)和帕瑞昔布+丙泊酚组(P组),每组50例。麻醉诱导前15min静脉注射帕瑞昔布钠加40mg和相同体积的生理盐水5ml。随后静脉推注丙泊酚,并在术中视患者麻醉情况适量追加。记录麻醉诱导时间、膀胱镜检查时间、丙泊酚用量、术后苏醒时间;记录HR、MAP>SpO2等牛命体征的变化;记录术中体动反应、呼吸暂停、低氧血症、心动过缓、低血压、注射痛及术后有关并发症的发牛情况。结
2、果与N组相比,P组的丙泊酚用量减少(P<0.05);低氧血症、低血压和呼吸暂停的发牛率明显降低(P<0.05)o结论帕瑞昔布在门诊无痛膀胱镜检查中具有良好的镇痛效果,并可有效降低不良反应发牛率。【关键词】帕瑞昔布钠;无痛膀胱镜;丙泊酚EfficacyofParecoxibinPainlessCystoscopythroughpreemptiveanalgesia.PengHui,ZhangQing,ChenHui-yu,HuBin.DepartmentofAnesthesia,SecondAffiliatedHospitalofNanjingMedicalUniversit
3、y,Nanjing210011,China[Abstract]ObjectiveToevaluatetheeffectsofParecoxibforpreemptiveanalgesiainPtientsundergoingPinlessCystoscopy.Methodslnadouble-blindstudy,100Patientsowererandomizedinto2group6(n二50each):Propofolgroup(groupN)andParecoxibcombinewithPropofolgroup(groupP)・IngroupN,Parecoxib40mgin
4、5mlofnormalsaline(N)wasinjecteclivover15minbeforeinductionofanesthesia.IngroupN5mlWasinjectedinsteadofParecoxib.Propofolwasinjectedivatlml//6suntildisappearanceofeyelashreflect.Cystoscopywasperformed.ThePtientswerebreathingspontaneously.Oxygenwasadministeredviafacemask.Additionalpropofolwasgiven
5、accordingtothePatientsresponetosurgicalstimuli.HR,MAP,SpO2,anesthesiainductiontime,Cystoscopytime,theamountofpropofoladministeredandrecoverytimewererecorded.Inadditionintraoperativebodymovement,apnea,hypoxemia,bradycardia,hypoteNion,injectionPinandpostoperativecomplicationwerealsorecorded.Result
6、sComparedwithgroupN,theamountofpropofoladministeredisfewer(P<0.05)andtheincidencesofintraoperativeapnea,hypoxemia,hypotension,islower(P<0.05).ConclusionIntravenousParecoxibhasgoodeffect.Besidesthat,theincidencesofintra-andpost-operativecomplicationwerelower.[Keywords]Parecoxib;PainlessCyst
7、oscopy;Propofol丙泊酚具有起效快,苏醒迅速,无蓄积等特点,在门诊无痛检查及手术中被广泛应用,大量文献报道⑴,其对患者呼吸、循环具有较强的抑制作用并II具有注射时疼痛的缺点,也为其在门诊中的使用埋下了安全隐患。但国内针对无痛膀胱镜的超前镇痛的研究相对较少。帕瑞昔布是特异性环氧化酶・2(COX-2)抑制剂,具有较强镇痛作用⑵。本院从2015年1月〜2016年7月对行无痛膀胱镜检查术的患者采用帕瑞昔布进行超前镇痛,应用效果良好,现报道如