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ID:27761098
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时间:2018-12-05
《医学毕业论文非何杰金淋巴瘤微血管密度及其血清bfgf水平》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、非何杰金淋巴瘤微血管密度及其血清bFGF水平姓名:2014年6月25日【关键词】碱性成纤维细胞生长因子TissuemicrovesseldensityandlevelsofserumbasicfibroblastgrowthfactorinpatientswithnonHodgkin'slymphoma【Abstract】AIM:Toexplorethelevelsofserumbasicfibroblastgrowthfactor(bFGF)andthetissuemicrovesselden
2、sity(MVD)innonHodgkin’slymphoma(NHL)patientswithdifferentclinicalandpathologicalfeatures.METHODS:In32NHLpatients(13newlydiagnosedand19inremissionafterchemotherapy)and10healthycontrols,ELISAwasusedtodetecttheirserumlevelofbFGFandFVUIRAGwasusedasthemar
3、kerofendothelialcellstodetectMVDin20casesofthe32NHLpatientsand10casesofbenignlymphadenopathy.Thestatisticttestwasusedtoanalyzethedifferenceamongdifferentgroups.RESULTS:ThemeanconcentrationsofserumbFGFintheuntreatedpatientsandpatientsinremissionafterc
4、hemotherapywere(7.6士1.2)ngL-1and(4.1±1.0)ngL-l,respectively,whichwerehigherthanthat[(1.7土1.4)pgL-1]inhealthycontrols(P0.05).TheserumbFGFlevelinTcelltypeNHLwassignificantlyhigherthanthatinBcelltype[(10.7士1.4)ngL-1vs(2.7士1.0)ngL-1,P0.05].ThemeanMVDofth
5、e20NHLcases(39土18)wasobviouslyhigherthanthatinbenignlymphadenopathygroup(13±5,P0.05)andthemeanMVDinTcelltypeNHLwassignificantlyhigherthanthatinBcelltype(47士15vs27士17,P0.05).CONCLUSION:TheNHLpatients,especiallythosewithTcelltypeNHL,havesignificantlyhi
6、gherserumbFGFlevelsandtissueMVDthancontrols.ThedatapresentedherestronglysuggestthatthebFGFmediatedangiogenesismaycloselybecorrelatedwiththepathogenesisandpathologiccharacteristicsinNHL.【Keywords】basicfibroblastgrowthfactor;nonHodgkin’slymphoma;ELISA;
7、microvesseldensity;immunohistochemistry【摘要】0的:分析不同临床特征和病理分型的非何杰金淋巴瘤(NHL)患者的血清碱性成纤维细胞生K:冈子(bFGF)水平及瘤性组织微血管密度(MVD)的差异.方法:收集32(初发未经化疗13,化疗后缓解19)例NHL患者及10例健康对照者血清,采用夹心ELISA法测定其bFGF水平;采用vWF抗体组化染色法检测其中20(T细胞型8,B细胞12)例NHL组织的MVD,以10例良性淋巴结病组织作为对照.统计学分析,采用t检验法
8、.结果:13例初发患者(7.6士1.2)ngL-1、19例化疗后缓解患者(4.H1.0)ngL-1的bFGF水平均显著高于健康对照(1.7±1.4)pgL-1,P0.05;初治患者与缓解患者问bFGF水平无统计学意义,但T细胞型(10.7土1.4)ngL-1显著高于B细胞型[(2.7H.0)ngL-1,P0.05].20例NHL及10例良性淋巴结病组织平均MVD分别为(39士18)和(13士5),相差显著(P0.05);T细胞型患者平均MVD明显高于B细胞型(47土15vs27土17,P0.05
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