不同剂量布托啡诺预防小儿全麻苏醒期躁动的临床观察

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1、不同剂量布托啡诺预防小儿全麻苏醒期躁动的临床观(杭州市红十字会医院浙江杭州310000)【摘要】目的：观察不同剂量布托啡诺用于预防学龄前小儿全麻术后苏醒期躁动的效果及安全性。方法：选择3〜6岁学龄前全麻患儿120例，随机分为四组.•A、B、C和D四组诱导时分别静脉输注布托啡诺0.5、1、2μg/kg和空白生理盐水,n=30。观察血流动力学改变，记录苏醒时间、PACU躁动程度、PACU停留时间、术后2h、6h镇静评分，同时观察术后呼吸抑制、嗜睡、恶心呕吐等不良反应发生情况。结果：A、B、C三组苏醒期躁动发生率与D组相比有统计学差异(P<0.05)；B>C组苏醒时间与D组相比有统计学差

2、异(P<0.05);B、C组术中各时点收缩压(SBP)、舒张压(DBP)和心率(HR)与D组相比有统计学差异(P<0.05);B、C组PACU停留时间与D组相比差异有统计学意义(P<0.05);B、C组术后嗜睡发生率与D组相比差异有统计学意义(P<0.05)。结论：0.5μg/kg布托啡诺能安全、有效地预防小儿全麻苏醒期躁动，不延长苏醒时间和PACU停留时间，不增加术后嗜睡的发生率。【关键词】布托啡诺；小儿；全麻；苏醒期躁动【中图分类号】R614【文献标识码】A【文章编号】1004-6194(2015)02-0368-02ClinicalObservationth

3、eEffectofDifferentButorphanolonEmergenceAgitationafterGeneralAnesthesiainPediatricsZHOUQing(RedCrossHospitalofHangzhou,ZhejiangHangzhou310000,China)【ABSTRACT】ObjectiveToinvestigatetheefficacyandsafetyofdifferentButorphanolonemergenceagitationaftergeneralanesthesiainpreschoolpediatricpatients.Methods

4、120preschoolpediatricpatientsaftergeneralanesthesiaweredividedintofourgroups,with30patientsineachgroup.ThepatientsinGroupA、B、CwereintravenousinjectedButorphanol0.5、1、2μg/kgafterinductionofanesthesia,andpatientsinGroupDwereintravenousinjectednormalsalinesolution.Changesofhemodynamicswererecordedaf

5、terinjection.Theincidenceandthedegreeofemergenceagitation,therecoverytime,thetimeofstayinginPACUand2hor6hObserver'sassessmentofalertness/sedation(OAA/S)scaleafteroperationwererecorded.Theincidenceofadversereactionsuchrespiratorydepression,lethargy,shivering,nauseaandvomitingandsoonwererecorded.Resul

6、tsTheincidenceofemergenceagitationingroupA>B、CweresignificantlylowerthaningroupDaftergeneralanesthesia(P<0.05).SBP、DBPandHRinGroupB、CdecreasedsignificantlycomparedwiththoseinGroupD(P<0.05).TherecoverytimeinGroupB、CweremuchlongerthanthatinGroupD(P<0.05).TheincidenceoflethargyinGroupB>Cwasmuc

7、hmorethaninGroupD(P<0.05).ConclusionItwassafeandfeasibletogiveButorphanol(0.5μg/kg)forreducingemergenceagitationaftergeneralanesthesiainpreschoolpediatricpatients,thetimeofstayinginPACUandrecove