北京密云地区宫颈液基薄层细胞学检测与人乳头瘤病毒检测对诊断宫颈病变的临床分析

《北京密云地区宫颈液基薄层细胞学检测与人乳头瘤病毒检测对诊断宫颈病变的临床分析》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、检丽析2018-03-2110:12:00中国现代医生2018年2期魏宝丽王海平［摘要］目的探讨宫颈液基薄层细胞学(Cytologyofcervicalfluidbase,TCT)检测与人乳头瘤病毒(Humanpapillomavirus,HPV)联合检测对诊断宮颈病變的临床分析，为更好地进行宮颈癌筛查提供依据。方法选取2014年1月1日〜2016年6月30日在本院就诊的7000例患者，其屮4500例单纯进行TCT检测，检测出459例阳性患者为TCT组；2500例进行TCT+HPV联合检测，检测出阳性(TCT、HPV只要有一项异常)患者363例为联合组。所有阳性患者均行阴道镜下活检，以病理组

2、织学结果为金标准，比较两组检测方法的效果。结果TCT组检出细胞学异常459例，检出率为10.2%(459/4500)；联合组检出阳性患者363例(其中TCT和HPV均阳性的共有234例；TCT阳性，HPV阴性的76例;TCT阴性,HPV阳性的53例)，检出率为14.5%(363/2500)。两组比较，差异有统讣学意义(P<0.05)。联合组宫颈商级别(CIN2及以上)病变检出率3.5%(87/2500)与TCT组1.5%(69/4500)比较，差异有统计学意义(P<0.05)。结论TCT+HPV联合组讨明显提高宫颈病变的筛査率以及宫颈高级别病变诊断的准确率，是医忠接受的理想方法。［关键词］T

3、CT;HPV；宫颈病变；宫颈癌［中图分类兮］R711［文献标识码］B［文$编号］1673-9701(2018)02-0054-03［Abstract］ObjectiveToinvestigatethecombineddetectionofcytologyofcervicalfluidbase(TCT)andhumanpapillomavirus(HPV)intheclinicaldiagnosisofcervicallesions,toprovideabasisforbettercervicalcancerscreening.MethodsAtotalof7000patientsadmitt

4、edinourhospitalfromJanuary1,2014toJune30,2016wereselected.Amongthem,4500casesweretestedbyTCTalone，and459positivepatientsdetectedwereasTCTgroup.2500casesunderwentthecombineddetectionofTCT+HPV,and363caseswithpositive(TCT,HPVaslongastherewasabnormalinoneterm)wereasthecombinedgroup.Allthepositivepatien

5、tsunderwentcolposcopicbiopsy.Choosinghistopathologicalresultsasthegoldstandard,theeffectivenessbetweentwotestmethodswascompared.Results459casesofcytologicalabnormalitiesweredetectedinTCTgroup,withadetectionrateof10.2%(459/4500).Inthecombinedgroup,363caseswerepositive(ofwhich234werepositiveforbothTC

6、TandHPV；76caseswereTCTpositiveandHPVnegative；53caseswereTCTnegativeandHPV-positive)twiththedetectionrateof14.5%(363/2500).Thedifferencebetweenthetwogroupswasstatisticallysignificant(P<0.05).Therewasastatisticallysignificantdifferenceinthedetectionrateofcervicalhigh-gradebetweenthecombinedgroup(3.5%

7、,87/2500)andtheTCTgroup(1.5%,69/4500).ConclusionThecombinationofTCT+HPVcansignificantlyimprovethescreeningrateofcervicallesionsanddiagnosisaccuracyofhigh-gradecervicallesions,whichistheidealmethodfordoctors