hs－crp与nt－probnp联合检测在合并慢性肾功能不全冠心病心力衰竭诊断中的应用价值

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1、Hs—CRP与NT-proBNP联合检测在合并慢性肾功能不全冠心病心力衰竭诊断中的应用价值高彦利王蔚浩胡忠栋王晓杰裴华广东省东莞市常平医院广东东莞523560【摘要】目的探讨合并慢性肾功能不全心力衰竭患者血浆N末端B型利钠肽原(NT-proBNP)、高敏C反应蛋白(Hs_CRP)水平的变化，为其在临床诊断预测屮的应用提供理论依据.方法选择我院2012年6月至2014年12月收治的确诊为合并慢性肾功能不全冠心病心力衰竭患者80例作为研究对象,以此作为本次的研究组,另选择80例未合并慢性肾功能不全冠心病心力衰竭患者作为

2、对照组，采用NYHA分级标准对患者心功能进行评定，比较NYHA心功能各级NT—proBNP和Hs—CRP水平.结果合并肾功能不全心衰患者NT—pro—BNP、Hs-CRP,年龄与非肾功能不全心力衰竭患者比较，差异有统计学意义(P<0.05)，性别无统计学差异，合并肾功能不全心力衰竭患者NYHA心功能各级NT-proBNP比较存在差异(P<0.05)，非合并肾功能不全心力衰竭组HYGHA心功能各级NT—proBNP及Hs—CRP比较存在差异.且各级间两两比较也存在差异，差异有统计学意义(P<0.05).结论血浆NT—

3、proBNP与Hs—CRP联合检测有助于合并肾功能不全心力衰竭的诊断及对心力衰竭程度进行分级.【关键词】NT—proBNP;Hs—CRP;肾功能不全；心力衰竭；分级ApplicationofHs—CRPandNT—proBNPindiagnosisofheartfailureinpatientswithchronicrenalinsufficiencyGaoYanli,WangWeihao,HuZhongdong,WangXiaojie,Pe旧ua【Abstract】Objective:Toinvestigatew

4、ithchronickidneyfunctionnotwholeheartfailurepatientswithplasmaN—terminalpro—B—typenatriureticpeptide(NTproBNP,changesinthelevelofhigh—sensitivityC—reactiveprotein(hsCRP),foritsapplicationinclinicaldiagnosisandpredictionprovidetheoreticaldaGta.Methods:ourhospit

5、alinJune2012to2014—Decemberconfirmedaswithchronicrenalfunctioninpatientswithcongestiveheartfailureandcoronaryheartdisease(CHD)80casesastheresearchobjectjnordertoasthestudygroup.Another80casesofpatientswithoutchronickidneyfunctionnotwholecoronaryheartdiseaseinp

6、atientswithheartfailureasthecontrolgroup,byNYHAclassificationstandardsforpatientsCardiacfunctionwasassessedbycomparingNTproBNPandHs—CRPIevelsinpatientswithNYHA.Results:NT—pro—BNP,Hs—CRP,ageandnonrenalfunctioninpatientswithcongestiveheartfailurepatientswithhear

7、tfailure,thedifferencewasstatisticallysignificant(P<0.05),genderandnosignificantdifferenceszcombinedwithrenalinsufficiencyheartfailurepatientswithNT—proBNPheartfunctionatdifferentlevelsofNT—proBNPandHYHAweredifferent/andthedifferencewasstatisticallysignificant

8、(P<0.0【5K)e.yCwoonrcdlsu】sion:thecombineddetectiono什is—CRPandNT—proBNPinplasmawashelpfultothediagnosisandclassificationofheartfailure.NT—proBNP;Hs—CRP;renalinsufficiency;heartfailu