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1、64例新生儿急性胆红素脑病早期改变时振幅整合脑电图的临床观察段玉会1王洲洪2苏萍1韦巧珍1(1广西玉林市第一人民医院新生儿科537000；2广西玉林市第二人民医院新生儿科537000)【摘要】目的通过对新生儿高胆红素血症患儿持续脑功能监测，探讨新生儿胆红素脑病早期改变时振幅盤合脑电图(amplitude-integratedelectroencephalographyaEEG)变化，为判断预后提供一定的参考。方法选择2012年1月一2013年6月在两家医院新生儿科收治64例胆红素水平≥320umol/I但无明显临床症状的足月儿，在入院后抽取血清查胆红
2、素水平同时行脑功能监测,并与脑干诱发电位(BrainstemAuditoryEvokedPotential,BAEP)结果比较。结果aEEG异常42例，异常率为65.6%，其屮轻度异常32例(66.6%),表现为背景不连续或连续正常电压合并单次惊厥；重度异常10例(23.8%),表现为背景波不连续，伴惊厥发作。64例患儿均行干诱发电位检查，aEEG轻度异常32例屮BAEP正常4例，轻度异常25例，屮度异常3例；aEEG重度异常10例屮BAEP屮度异常6例，重度异常4例。结论振幅整合脑电图可反应新生儿胆红素脑病的早期脑损伤变化，并与BAEP异常分级存在相关性
3、；可作为急性胆红素脑病早期诊断依据。【关键词】振幅整合脑电图，脑功能，新生儿胆红素脑病【屮图分类号】R722.12【文献标识码】A【文章编号】2095-1752(2014)14-0122-0364casesofneonatalacutebilirubinencephalopathyintheearlyclinicalobservationofamplitude-integratedelectroencephalographychangeDuanyuhuilWangzhouhong2SupinglWeiqiaozhenlDepartmentofNeonato
4、logy,YulinFirstPeople’sHospital,Yulin537000,China【Abstract】ObjectiveThroughtothenewbornchildrenwithhighbloodbilirubinbrainfunctionmonitoringcontinuously,toobservethechangeofearlyneonatalbilirubinencephalopathywhenamplitude-integratedelectroencephalography(aEEG)changestorProv
5、idecertainreferenceforprognosis.MethodsChoiceinJanuary2012-June2013intwoneonataldepartmenttreated64casesofbilirubinlevelsof320umol/l,butnoclinicalsymptomsfull-terminfant.Extractserumafteradmissionbloodbilirubinlevellinesofbrainfunctionmonitoringatthesametime,AndcomparedwithBrainst
6、emAuditoryEvokedPotential(BAEP).ResultsAbnormalaEEG42cases,theabnormalratewas65.6%,themildabnormal32cases(66.6%),showedthebackgrounddiscreteorcontinuousnormalvoltagecombinedsingleconvulsions;andseverelyabnormal10cases(23.8%),showedthebackgroundwavesofdiscontinuity,withseizure.Stem
7、evokedpotentialexaminationin64cases,aEEGmildlyabnormalBAEPin32caseswith4caseswerenormal,mildlyabnormal25cases,moderatelyabnormal3cases;inseverelyabnormalaEEG10casesmoderatelyabnormalBAEPin6cases,severelyabnormal4cases.ConclusionaEEGcanresponseamplitudeneonatalbilirubinencephalopat
8、hyintheearlybraininjuryofchange,G
