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1、2型糖尿病患者血清Ghrelin水平与肥胖、胰岛素抵抗的相关研宄郭大敏吴和波劳程强曾灶英(广东省佛山市南海区第八人民医院528216)【摘要】目的探讨糖尿病患者血清Ghrelin水平与肥胖、胰岛素抵抗之间的关系。方法将300例2型糖鉍病患者根据BMI分为体重过低、体重正常、超重和肥胖4组；采用EUSA法测定血清屮Ghrelin水平变化；用直线相关及多元逐步回归分析血清Ghrelin与上述指标的相关性。结果糖尿病肥胖组的Ghrelin水平显著低于糖鉍病体重过低组、体重正常组和超重组(p<0.05),而且随着BMI增加而减少；糖尿病患者血清Gh
2、relin与BMI、HOMA-IR、FINS和WHR呈显著负相关(r=-0.728,p<0.01;r=-0.562,p<0.01；r=-0.490,p<0.01；r=-0.389,p<0.01)；BMI是影响血淸Ghrelin水平的最重要变量。结论BMI是糖姒病患者血清Ghrelin水平的主要相关因素；Ghrelin参与丫体脂形成和胰岛素抵抗的变化，在糖尿病的发病过程屮起着重要作用。【关键词】糖鉍病Ghrelin肥胖胰岛素抵抗【中图分类号】R587.2【文献标识码】A【文章编号】2095-1752(2013)26-0030
3、-02ThestudyofrelationshipsbetweenserumGhrelinlevelsandobesity,insulinresistanceinpatientswithtype2diabetesmellitusGuodaminwuhebolaochengqiangzengzaoyingNanhaidistrict,foshancity,guangdongprovince,theeighthpeople'shospitalFoshan528216,Guangdong【Abstract】ObjectiveToinvestigatet
4、herelationshipsoftheserumGhrelinlevelsandobesity,insulinresistance.Methods300type2diabeticmellituscasesweredividedinto4groupsaccordingtoBMI,whichwerenamedbyunderweightgroup,normalweightgroup,overweightgroupandobesegroup,respectively.ThelevelsofGhrelinwasmeasuredbyELISA.Therel
5、ationshipsamongserumGhrelinconcentrationswithalltheindexeswereexploredbylinearcorrelationandmultiplestepwiseregressioncorrelationanalysis.ResultsIntheobesediabetes,theserumghrelinwassignificantlylowerthanthatoftheotherthreegroupsdiabetes(p<0.05)andwasdecreasedwiththeincrem
6、entofBMl.TheserumghrelinofthediabeteswasnegativelycorrelatedwithBMI,HOMA-IR,FINSandWHR(r=-0.728,p<O.Ol；r=-0.562,p<O.Ol；r=-0.490,p<O.Ol；r=-0.389,p<O.Ol).TheBMIseemedtobethebestvariableinpredictingserumghrelinlevels.ConclusionTheBMIisthedeterminativefactorinserumghr
7、elinlevel,andGhrelintakespartinbodyfatformationandchangesofinsulinresistancewhichmayindicatethatGhrelinplaysimportantroleinthepathogenesisofdiabetesmellitus.【Keywords】DiabetesmellitusGhrelinobesityinsulinresistance糖尿病(diabetesmellitus)患病率呈全球性增加，己成为继心血管病和肿瘤之后的第三大非传染性疾病，因此奋关糖尿病
8、病因及发病机制的研究tl益增多并不断深入。新近的研究发现，小分子脑肠肽Ghrelin除具有调节生长激素(GH)分泌、参与能量平衡的调节外
