甲型h1n1 流感患者外周血细胞计数与病情严重程度的关系研究

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1、甲型H1N1流感患者外周血细胞计数与病情严重程度的关系研究蒋明彦1,刘国平1，曾建平1*，赵子文2，付杰伟1，刘康1，袁光雄11湘潭市中心医院呼吸科,湘潭4111002广州市第一人民医院呼吸内科,广州510180【摘要】:目的探讨甲型H1N1流感患者外周血细胞计数与病情严重程度之间的关系。方法　将本院300例甲型H1N1流感患者根据病情的严重程度分为普通病例组和重症及危重病例组，比较两组外周血细胞计数;采用Logistic回归模型对甲型H1N1流感患者重症及危重病例与外周血细胞计数的相关性进行分析。结果外周血白细胞数，淋巴细胞数与预后相关(P＜0.05)；用Logistic回归方程对300

2、例甲型H1N1流感患者进行回顾性验证，结合外周血白细胞数、淋巴细胞数对甲型H1N1流感患者中重症及危重病例判断的总正确率为85.1％。该方程的敏感性为70.4％，特异性为98.8％。结论　外周血白细胞数、淋巴细胞数联合分析能提高对甲型H1N1流感患者中重症及危重病例判断的准确性。【关键词】:甲型H1N1流感；重症及危重病例;外周血细胞计数;Logistic回归模型ArelationshipStudybetweenperipheralbloodcellcountsofpatientswithH1N1influenzaAandseverityofpatients'condition.JIANG

3、Ming-yan1,LIUGuo-ping1,ZENGJian-ping1,ZHAOZi-wen2，FUJie-wei1,LIUKang1,YUANGGuang-xiong1（1、XiangtanCentralHospital，Xiangtan4111002、Guangzhoufirstpeoplehospitalbreathinternalmedicinedepartment,Guangzhou510180）ABSTRACTObjective:Toinvestigatetherelationshipbetweenperipheralbloodcell*通讯作者：曾建平（J8283174@

4、SOHU.COM）countsofpatientswithH1N1influenzaAandseverityofpatients'condition.Methods:Atotalnumberof300patientswithH1N1influenzaAfromauthorshospitalweredividedintonormal-conditiongroupandsevere-and-critical-conditiongroup,peripheralbloodcellcountsofeachgroupwerecompared.Therelationshipamongconditiono

5、fpatientswithsevereorcriticalH1N1influenzaAandpatients'peripheralbloodcellcountswasanalyzedusingstep-wiselogisticregressionmodel.Results:Countsofperipheralleukocytesandlymphocytesarecorrelatedwithpatients'prognosis(p<0.05).All300patientswereretrospectivelyanalyzedusingstep-wiselogisticregressionmo

6、del,whichshowstheoverall-accuracyofestimatingsevereorcriticalconditionusingcombinedanalysisofperipheralperipheralleukocytesandlymphocytescountsis85.1%,sensibilityofanalysisequationis70.4%,specificityis98.8%.Conclusion:Combinedanalysisofperipheralleukocytesandlymphocytescountsmayimprovetheaccuracyo

7、festimatingthesevereorcriticalconditionofpatientswithH1N1influenzaA.Keywords:H1N1influenzaA,severeorcriticalpatients,peripheralbloodcellcount,step-wiselogisticregressionmodel2009年3月，墨西哥暴发“甲型H1N1流感”疫情，并迅速在全球范围内蔓延。