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1、-成都中医药大学2014届硕士学位论文AbstractThedrugtasteeffectscomplianceofpatients.Manydrugsaretoobittertoswallow,restrictedinformulationdevelopmentandclinicaluse.Meanwhilebitterdrugscanalsocausegreatpsychologicalandphysicalburdentopatients,especiallychildren,theelderlyandpatientswithpoorappe
2、tite,andcouldeasilyleadtorefuseserviceandvomiting.TheilltasteproblemoftraditionalChinesemedicineisespeciallyserious,mosttraditionalChinesemedicinehavestrongbadtaste.Therefore,thisthesistakedapplicationoftaste-maskingtechnologyintraditionalChinesemedicineastheobject.Thebitterme
3、dicineAndrographiswasselectedasthemodeldrug.Bythemoldingprocessselectionandoptimization,whichwasmadeintogranules.Thenaddflavoringagents,usingvolunteerstastingdrugsandtheelectronictongueanalysingdrugstoevaluatetaste-maskingeffects.Screenoutthebettertaste-maskingprescriptionstoi
4、mprovementorhideAndrographisbitter.Themaincontentsareasfollows:Withtheindexofgranulesformability,moistureabsorption,particlestate,withorwithoutcaking,bulkdensity,angleofrepose,meltingresistance,hardness,sizedistributionandsoon,theformationtechniqueinvolvingthesortsandthepropor
5、tionoftheadditives,wettingagentconcentrationwasdeterminedbysinglefactortest.TheresultsdeterminetheselectionofthemoldingprocessasAndrographisparticulatematerialswasdextrin,andtheratioofAndrographisdrypowderanddextrinwas1:2,wettingagentwas75%ethanol.Onthisbasis,addflavoringagent
6、s,studyonthetaste-maskingofAndrographisgranules.Volunteerstasteddrugsandevaluatedtaste-maskingeffects,usingcomprehensivescoremethodtoscreenoutthreebettertaste-maskingprescriptions.ThebestprescriptionwastheratioofAndrographisdrypowderanddextrin1:2,APM0.3%,AK0.2%,HPMCk4M1.0%,cit
7、ricacid0.8%,NaCl1.0%.Usingtheelectronictonguetoanalyzedthethreebettertaste-maskingprescriptions,theresultswere----II万方数据----成都中医药大学2014届硕士学位论文consistentwiththeresultsofVolunteerstasteddrugs.DefinethequalitystandardsofAndrographisextractandgranules,includingcharacter,TLC,HPLCco
8、ntentofandrographolideanddehydroandrographolideandotherprojec
