埃索美拉唑镁肠溶微丸片剂的研制

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1、-目录目录摘要.................................................1Abstract.............................................3前言.................................................6第一章埃索美拉唑镁含量测定方法的建立...............121仪器和试药..........................................121.1仪器..................................

2、..............121.2药品与试剂..........................................122方法与结果..........................................132.1色谱条件............................................132.2含量测定............................................132.3专属性试验..........................................142.4标准曲线的建立.

3、.....................................152.5精密度试验..........................................162.6重现性试验..........................................172.7准确度试验..........................................172.8埃索美拉唑镁的释放度测定方法........................182.8.1测定方法........................................

4、......182.8.2处方间释放行为相似程度的比较（相似因子f2的比较）.....183本章小结............................................19第二章埃索美拉唑镁肠溶微丸的制备...................20I----万方数据----目录1仪器和试药..........................................201.1仪器................................................201.2药品与试剂..........................

5、................202方法与结果..........................................212.1流化床工艺参数......................................212.2EudragitL30D-55和EudragitNE30D混合包衣液为肠溶衣.212.8.1载药层制备............................................222.2.1.1载药层的包衣液处方......................................222.2.1.2操作步骤..

6、..............................................222.2.1.3微丸粒径分布............................................222.8.2隔离层的制备..........................................232.2.2.1隔离层的包衣液处方......................................232.2.2.2操作步骤................................................232.2.2.3微

7、丸粒径分布............................................232.8.3肠溶层的制备..........................................242.2.3.1肠溶层的包衣液处方......................................242.2.3.2操作步骤................................................242.8.4耐酸性试验............................................2