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1、2.实验研究目的：本研究旨在通过对糖尿病、糖尿病脾虚证、脾虚证模型大鼠的胃肠激素及其相关性的研究，探讨糖尿病状态下脾虚证的病理生理意义，揭示脾虚证的本质，探讨病证之间的互动关系。研究方法：建立糖尿病、糖尿病脾虚证、脾虚证大鼠模型后处死，观察各组血糖、胰高血糖素样肽-1（glucagon-likepeptide1，Glp-1）、胰岛素（insulin,Ins）、胰高血糖素（glucagon,Gln）、抑胃肽（gastricinhibitorypolypeptide,GIP）、胃泌素（gastrin,Gas）等指标的差异。
2、结果：经统计学分析，脾虚组的GLP-1明显高于糖尿病组和糖尿病脾虚组,糖尿病组与糖尿病脾虚组之间未见明显差异,正常组与其他各组之间均未见明显差异。糖尿病组和糖尿病脾虚组的Ins明显高于正常组和脾虚组,糖尿病组与糖尿病脾虚组、脾虚组与正常组之间无明显差异。脾虚组的Gln明显低于糖尿病组和糖尿病脾虚组,糖尿病脾虚组明显高于正常组,糖尿病组与糖尿病脾虚组之间、正常组与脾虚组及糖尿病组差异无统计学意义。四组的GIP无显著性差异，但脾虚组明显低于糖尿病脾虚组。糖尿病组和糖尿病脾虚组Gas明显高于脾虚组；糖尿病组和糖尿病脾虚组高于
3、正常组，其差异具有统计学意义；糖尿病组与糖尿病脾虚组之间差异无统计学意义；脾虚组与正常组之间无明显差异。糖尿病大鼠GLP-1与血糖呈负相关，与GIP呈正相关。结论：GLP-1降低和Gas升高可能是糖尿病及糖尿病脾虚证的病理实质的组成部分；脾虚证及糖尿病脾虚证时机体具有自我调节的能力；糖尿病及糖尿病脾虚证与单纯脾虚证之间具有明显差异，提示临床上应先辨病后辨证，在疾病诊断明确的情况下进行辨证论治。关键词胃肠激素；脾虚证；糖尿病脾虚证；自我调节ClinicalObservationappliedStrengtheningt
4、heSpleenandReplenishingQiofDiabetesofDeficiencySpleenandStudyonGastrointestinalHormonesSpecialty:InternalMedicineofTraditionalChineseMedicineAuthor:ZhangJingTutor:Prof.SunFengleiAbstractThispaperincludingclinicalresearchandexperimentalstudytwoparts.1.Clinicalres
5、earchObjective:Thisstudyaimedtoexploretheroleofspleeninthepathogenesisoftype2diabetes,andStrengtheningtheSpleenandReplenishingQiclinicalefficacyoftreatmentoftype2diabetesspleendeficiency,andrevealtheclinicalfeaturesoftype2diabetespatientswithspleendeficiencysynd
6、rometoprovethattheJianPiJiangTangYiniseffectiveprescriptionforthetreatmentoftype2diabetes.Methods:Inthisstudy,selectedfromtheclinicaltype2diabetes60cases,30caseswererandomlydividedintotwogroups,thetreatmentgroupandcontrolgroup(30cases).ThetreatmentgroupreceivedJ
7、ianPiJiangTangYin,metforminhydrochlorideenteric-coatedtablets,acarbose(Glucobay);thecontrolgroupwasgivenmetforminhydrochlorideenteric-coatedtablets,acarbose(Glucobay).After8weeksoftreatmenteffectswereobserved.Results:Statisticalanalysis,thegeneralinformationofth
8、etreatmentgroupandcontrolgroupbeforetreatment,includinggender,age,courseofdisease,fastingglucose,2-hourpostprandialbloodglucose,glycosylatedhemoglobin,Chinesemedicine
