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1、www.zglckf.com王联群，等.表皮干细胞增殖分化的调控机制综述表皮干细胞增殖分化的调控机制*☆王联群1，刘德伍2RegulatorymechanismofproliferationanddifferentiationofepidermalstemcellsWangLian-qun1,LiuDe-wu21IntensiveCareUnit,2InstituteofBurn,FirstAffiliatedHospital,NanchangUniversity,Nanchang330006,JiangxiProv
2、ince,ChinaWangLian-qun☆,Studyingfordoctorate,Associateprofessor,Associatechiefphysician,IntensiveCareUnit,FirstAffiliatedHospital,NanchangUniversity,Nanchang330006,JiangxiProvince,Chinawlq1029@tom.comCorrespondenceto:LiuDe-wu,Doctor,Chiefphysician,Doctoralsuper
3、visor,InstituteofBurn,FirstAffiliatedHospital,NanchangUniversity,Nanchang330006,JiangxiProvince,Chinadewuliu@126.comSupportedby:theNationalNaturalScienceFoundationofChina,No.30560058*Received:2008-01-08Accepted:2008-08-15南昌大学第一附属医院，1ICU，2烧伤研究所，江西省南昌市330006王联群☆，
4、女，1971年生，浙江省宁波市人，汉族，南昌大学医学院在读博士，副教授，副主任医师，主要从事创伤修复的研究。wlq1029@tom.com通讯作者：刘德伍，博士，主任医师，博士生导师，南昌大学第一附属医院烧伤研究所，江西省南昌市330006dewuliu@126.com国家自然科学基金资助项目(30560058)*中图分类号:R394.2文献标识码:A文章编号:1673-8225(2008)47-09343-04收稿日期：2008-01-08修回日期：2008-08-15(54200805080005/WL·Q)Ab
5、stract:Astheskintissue-specificstemcells,epidermalstemcellshavethepotentialityofmulti-directionaldifferentiationandself-duplication.Therefore,epidermalstemcellscouldserveastheseedcellsforskintissue-engineered.However,theregulatorymechanismofdifferentiationandpr
6、oliferationonepidermalstemcellsisunclear.Theresearchonepidermalstemcellshasfocusoncorrelativepathwaysofsignalingtransductionatpresent,suchasMAPK,Wnt,Notch,bonemorphogeneticproteinsignalingpathway.Theexpressionlevelofdifferentiationandproliferationrelatedgeneexc
7、hangethroughactivatingsignalingpathway,whicheventuallyregulatedifferentiationandproliferationofepidermalstemcells.Itisshownthattheinductionandthereinforcementofthetelomerasereversetranscriptaseactivitymayhaveimportantinfluenceonthemaintenanceoftheself-renewalan
8、dproliferationabilityoftheepidermalstemcells.Theresearchonepidermalstemcellhasattractedmoreandmoreinterestsoftheresearchers.Epidermalstemcellsarenowextensivelyappliedinmanye
