组合型人工肾对慢性肾衰患者血清瘦素、同型半胱氨酸及甲状旁腺素水平的影响论文

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1、组合型人工肾对慢性肾衰患者血清瘦素、同型半胱氨酸及甲状旁腺素水平的影响论文【摘要】目的：探讨血液灌流加血液透析对慢性肾衰患者血清中瘦素（Leptin)、同型半胱氨酸（tHcy）及甲状旁腺素（iPTH)的清除作用，并与单纯血液透析清除Leptin、tHcy、iPTH的效果比较。方法：在25例慢性肾衰患者常规血液透析中增加一次血液透析加灌流治疗，在透析及透析加灌流前后分别检测其Leptin、tHcy、iPTH血清水平，结果表明血透加灌流治疗后较治疗前明显降低（P0.01），且较单纯血液透析明显降低（P0.05）,而单纯血液透析前后血清Leptin、tHcy、

2、iPTH水平没有改变（P0.05）。结论：血液灌流可以明显降低慢性肾衰患者血清中的Leptin、tHcy、iPTH水平，从而改善透析患者的生活质量，减少营养不良、心血管疾病和肾性骨病和异位钙化并发症的发生。【关键词】血液透析；组合型人工肾（血液灌流联合血液透析）；瘦素；同型半胱氨酸；甲状旁腺素【ABSTRACT】Objective:Tostudytheclearingeffectsabouthemoperfusionassociatedodialysisonparathyroidhormone(PTH),Leptinandtheplasmahomocys

3、teine（tHcy）inchronichemodialysispatients.Methods:25patientsoperfusioninbinationodialysis(HD+HP).PlasmaPTH,Leptinandtheplasmahomocysteine（tHcy）easuredinplasmainpreandposttreatmentbymeansofradioimmunoassay.Conclusion:bloodpurificationoperfusionplushemodialysismaydecreaseplasmaPTH,

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