四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响

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1、四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响【摘要】探讨四生汤对甲状腺激素致阴虚证小鼠的治疗作用及机制。方法：选取健康昆明小鼠60只，随机分成6组。正常组和阴虚模型组予蒸馏水灌胃，低、中、高剂量四生汤组为治疗组，生脉饮为阳性对照药物，观察各组小鼠的一般生活状况并检测其自由活动能力和血清丙二醛的含量。结果：四生汤能明显改善阴虚模型小鼠的口干、烦躁和体温升高（P＜0.05），提高小鼠的自由活动能力（P＜0.05），降低血清丙二醛的含量（P＜0.05）；但与生脉饮比较，差异无统计学意义（P＞0.05）。结论：高、中剂量四生

2、汤具有良好的养阴清热、生津止渴作用，可提高机体的活动能力和抗氧化损伤。【关键词】四生汤阴虚身体活动抗氧化剂小鼠ZhangSF,ChenZ,LiB,ChenHY,LingCQ,ed/ZhongXiYiJieHeXueBao.2008;6(10):10291033.RecEivedMarch4,2008;publishedonlineOctober15,2008.Freefulltext(PDF)isavailableat.jcimjournal..Indexed/abstractedinandfulltextlinkout

3、atPubMed.For20081008OpenAccessEffectsofSishengDecoctiononspontaneousactivityandserumconcentrationofmalondialdehydeinmiceeSufangZHANG1,2,ZheCHEN1,BaiLI1,HongyunCHEN1,ChangquanLING1,Xinyuedicine,ChanghaiHospital,SecondMilitaryMedicalUniversity,Shanghai200433,Chin

4、a2.DepartmentofIntegratedTraditionalChineseandedicine,PulmonaryHospital,TongjiUniversity,Shanghai200433,China3.DepartmentofBiochemistry,ChinesePeople'sLiberationArmyGeneralHospital,BEIjing100088,ChinaObjective:ToassessthetherapeuticeffectsofSishengDecoction,apoundt

5、raditionalChineseherbalmedicine,onamousemodelofyindeficiencysyndromeinducedbythyroidhormone,andtomakethepreliminarystudyonitsmechanisms.Methods:Simultaneousmodelingandtreatmenticelydividedintosixgroups:normalgroup,yindeficiencymodelgroup,loediumandhighdoseSisheng

6、DecoctiongroupandShengmaioralliquidgroup.Normalgroupandyindeficiencymodelgroupinisteredconcentrationofmalondialdehydeindifferentgroupsptomsofyindeficiencysyndromesuchasxerostomia,dysphoriaandfervescenceprovedintheSishengDecoctiongroups.paredodelgroup,thespontaneous

7、activityconcentrationofmalondialdehydeaioralliquidgroup(P<0.05).Conclusion:MediumorhighdoseSishengDecoctioniseffectivefornourishingyin,clearingheat,engenderingliquidandallayingthirst.TheaboveeffectsofSishengDecoctionmayberealisedbyimprovingthespontaneousactivi

8、tyandresistingoxidativedamage.Keyice恶性肿瘤患者放疗后往往出现纳呆、口干、口苦、盗汗、五心烦热、夜寐不安等症状，在中医里属于气阴两虚证的范畴，因此用健脾益气、养阴清热类中药能够明显改善患者的上述症状，从而提高放疗的完成率［1］。上海长海医院在临床中应用四