波尔定对胶原诱导性关节炎大鼠的治疗作用及对继发性骨质疏松骨微结构的影响

《波尔定对胶原诱导性关节炎大鼠的治疗作用及对继发性骨质疏松骨微结构的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、Meanwhile，HEstainingwasexecutedtoobserVethehistopath0109ychangesoftheanⅪeandimmunohistochemicalstainingmethodcarriedouttodetecttheexpI．essionleVelofIL一1OandIL一17inlocalratanl(1ejoint．Aswellasindicesofthymusandspleenwasobse]rVed．AllofthesewerecompletedtoeValu

2、atetheefjfectofb01dineandexploretheirmechanism．Thentakethevertebrae(1umbar)andfemurforthedetectiononBMDandmicro—CT．Results：lEValuationan¨tisindeXandgeneralstate：Comparedwithblankcontrolgroup，ratsofmodelgrouphadsignificantlyweightloss，actiVitiesreducedandspir

3、itwaspoor．ProgressionofarthritissyIllptomaRerbuildingespeciallyasthesymmetrichind1imbsjoimsignificantly．Thepeakofanntisperf．oHIlanceappearsin4weeksaRertheimmune，thengraduallyintothechronicphasewithjointstifmessanddefomity．2Anl(1ejointswellingandhistopath0109

4、icalresultsshowed：thehighdoseofboldinegroupcouldsigni6cantlyaUeViatethedegreeofinflammationinmodelrats．Duringtreatment，onday1O，AIValuesofhighdoseofboldinegroupwaslowerthanthatoftheCIAgroup(尸

5、cantly10werthanthatoftheCIAgroup俨

6、totheMTXgroup，otherdmggroupshaddifferentdegreereliefinpath0109icalchangesofthear墩1ejoint，especiallythehighdoseofb01dinegroup．3CytokineleVelsaccordingtotheresultsshowed：ComparedwimtheblaI山contr01group，IL一1Osemm1eVelsinCIAgrouphadsignificantlydecreased俨

7、0therdmggrouphaddif．ferentincreasedinIL一1Osemm，especiallythehighdoseofboldinegroup．4BMDon1umbartotheresultsshowed：Comparedwithblankcontr01铲oup，BMDofCIA铲oupobViously10wer(尸

8、icro—CTofproximalf．emurtotheresultsshowed：Comparedwiththeblarll(contr01group，boneV01ume／totalVolume(BV／TV)，tra【becularnuHlber(Tb．N)andtrabecularthicl(Iless(Tb．Th)inCIAgroupsignificantlydecreased