癫痫患者认知功能损害的特点、影响因素及其与血清igf-1水平的相关性研究

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1、授予单位代码10089学号或申请号20153224中国图书分类号R742.1HebeiMedicalUniversity硕士学位论文文文专业学位癫痫患者认知功能损害的特点、影响因素及其与血清IGF-1水平的相关性研究研究生：吴建坤导师：王维平教授专业：神经病学二级学院：河北医科大学第二医院2018年3月目录中文摘要······································································································1英文摘要···························

2、·························································2英文缩写······························································································4研究论文癫痫患者认知功能损害的特点、影响因素及其与血清IGF-1水平的相关性研究前言·····························································································

3、···············5材料与方法····························································································6结果·································································································8附图············································································

4、···········11附表················································································12讨论··················································································16结论·······················································································22参考文献··············

5、····································································22附录·······················································································28综述癫痫患者认知功能康复研究···································29致谢··············································································

6、···························39个人简历························································································40中中中文文文文摘摘摘摘要要要要癫痫患者认知功能损害的特点、、影响因素及其与血清、影响因素及其与血清IGF-1水平的相关性研究摘要目的：探讨癫痫患者认知功能水平及其损害的特点，分析认知功能的影响因素,及其与血清胰岛素样生长因子-I（IGF-1）水平的相关性。方法：本研究记录癫痫患者临床资料、抗癫痫药物（AEDs）使用情况及脑电图结果等，采

7、用蒙特利尔认知评估量表（MoCA）对50例癫痫患者及30例健康者进行认知功能评定，采用酶联免疫吸附试验（ELISA）检测血清IGF-1表达水平。结果：1.癫痫患者MoCA总分、视空间执行、命名、记忆、注意力、语言、定向力得分、血清IGF-1表达水平均低于对照组（P＜0.05）。2.不同教育程度、脑电图异常情况的癫痫患者MoCA评分差异有统计学意义（P＜0.05）。教育水平越高，认知评分越高；脑电图存在癫痫样异常放电，认知评分低。3.癫痫患者MoCA评分与病程呈负相关（P＜0.05）,与血清I