难治性癫痫患者认知功能评估及影响因素分析

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1、授予单位代码10089学号或申请号—20122540蚵於(E钭大5HebeiMedicalUniversity硕士学位论文科学学位难治性癫痫患者认知功能评估及影响因素分析研究生：张波导师：赵文清教授李文玲教授专业：外科学二级学院:河北省人民医院河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研宄成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相

2、应法律责任。研宂生签名导师签章：二级学院领导盖章:lyo丨’年j月4河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。目录中文摘要··············································································1英文摘要································································

3、··············4英文缩写··············································································7研究论文难治性癫痫患者认知功能评估及影响因素分析前言··············································································8材料与方法·····································································9结果··················

4、···························································14附图·············································································16附表·············································································21讨论·········································································

5、····25结论·············································································30参考文献·······································································31综述癫痫与认知·································································35致谢··························································

6、·························52个人简历·············································································53中文摘要难治性癫痫患者认知功能评估及影响因素分析摘要背景：癫痫是中枢神经系统中仅次于脑血管病的第二常见病，世界各地的报告显示癫痫发病率约为20-50／10万／年。据世界卫生组织估计全球大约有5000万癫痫患者。根据调查，我国的发病率约为35／10万／年，患病率约为0.4%，高发区甚至达1%，大约有600万癫痫患者，同时每年新增癫痫患者约40万。在癫痫患者中，有20%-30%

7、的患者通过药物治疗不能有效控制，称为难治性癫痫。癫痫不仅给患者的生活和工作带来了严重的影响，同时也给家庭、社会带来了沉重的负担。癫痫的反复发作可以严重影响患者的认知功能。认知功能指人类各种有意识的精神活动，学习知识、运用知识的能力,包括计算能力、抽象概括能力、判断能力、记忆力等多种能力。据报道，80％以上的癫痫患者认知功能低于正常人，其中[1]50％以上具有明显认知功能缺陷，癫痫与认知功能的关系是目前临床和科研的研究热点