大果山楂黄酮类物质的提取及其抗氧化性和降血脂功能研究

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1、万方数据modeling．XuezhikangcansignificantlyreduceserumTC，TG(P<0．O1)，andincreaseHDLCanddecreaseLDLC．SoXuezhikanghasgoodlipid—loweringeffect，carlbeusedasapositivecontroldrugexperiment．Afterfeeding，Chinesehawthornflavonoidslow,middleandhighdosegroupwereabletomakethecontentofserumandliverdecreaseinTC，TGand

2、thehighdosegroup(300mg／kgbw／d)wassignificantly(P<0．05)low．ButtheflavonoidsofMalusdomeri(Bois)Chev．hasnosignificanteffectonHDLCcontentandLDLCcontentinserumrP>0．05)．Ithasadecreasingeffectonthebodyweightandorganindexinhyperlipidemicmice，buttheeffectisnotsignificant．7、EffectofMalusdomeri(Bois)Chev．flav

3、onoidsonthetotalantioxidantcapacityandantioxidantenzymes：comparedwiththenormalgroup，theserumlevelsofSODandT-AOCinexperimentalmicehyperlipidemiamodelgroupweresignificantlyreduced，indicatingthatthetotalantioxidantcapacitydecreasedinhi曲fatgroup．Malusdomeri(Bois)lChev．flavonoidsgroupsCanimprovetheserum

4、SODandT-AOC，anditshowedacertaindoseeffectrelationship．Thehi曲dosegroup(300mg／kgbw／d)hasansignificantinfluence(P<0．05)．ForthelivertissueSOD，middledoseandhighdosegroupwasverysignificant(P<0．01)，buttheT-AOCvalueseldomchangedinthelivertissue．ThedifferencebetweengroupseffectwasnotsignificantfP>0．05)．KEYW

5、ORDS：Malusdomeri(Bois)Chev．；flavonoid；extraction；anti-oxidantactivity；hypolipemiceffectVI】万方数据目录摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯IA陷TR^CT⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯IV第一章绪论⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．11．1大果山楂简介⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯11．2大果山楂主要活性成分⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯11-2．1黄酮类化

6、合物⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．11．2．2熊果酸⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．21．2．3单体有机酸类⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．21．2．4其他成分⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．21．3大果山楂药理功能⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯21．3．1心血管系统功能⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯31．3．2对自由基的清除作用⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯31．3．3胃肠系统功能⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯31．3．4护

7、肝作用⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．31．3．5抑菌作用⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．41．3．6对免疫系统的影响⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯41．4大果山楂黄酮研究进展⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯41．5植物黄酮常见的提取分离方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯51．5．1提取方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯